Effect of Anti-Insulin Receptor Antibody on Insulin Dissociation from IM-9 lymphocytes.
Effect of Anti-Insulin Receptor Antibody on Insulin Dissociation from IM-9 lymphocytes.
复制标题
抗胰岛素受体抗体对 IM-9 淋巴细胞胰岛素解离的影响。
DOI：
10.1055/s-2007-1019311
复制
发表时间：
1981
期刊：
影响因子：
--
通讯作者：
Ludeman,CH
中科院分区：
文献类型：
--
作者：
Blackard,WG;Ludeman,CH
Although anti-insulin receptor antibodies mimic insulin in many of its actions, antireceptor antibodies in serum from a diabetic patient did not share the property of insulin to produce negative cooperativity as defined by the DeMeyts experiment. In contrast, an inhibition of insulin dissociation from IM-9 lymphoblastoid cells was observed after exposure to the antireceptor antibody. The capacity of this particular antireceptor antibody to attach to cells whose insulin receptors have been saturated suggests that the antibody may trap insulin by molecular hindrance.
