Aerobic fitness is associated with gray matter volume and white matter integrity in multiple sclerosis.
Aerobic fitness is associated with gray matter volume and white matter integrity in multiple sclerosis.
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DOI：
10.1016/j.brainres.2009.06.063
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发表时间：
2010-06-23
期刊：
影响因子：
2.9
通讯作者：
Kramer AF
中科院分区：
文献类型：
--
作者：
Prakash RS;Snook EM;Motl RW;Kramer AF
在多发性硬化症患者中，灰色和白色物质的改变已被充分证明。这种脑组织损伤的严重性和程度与认知障碍、疾病持续时间和神经功能障碍相关，使得组织损伤的定量指标成为疾病进展的重要标志物。在这项研究中，我们调查了心肺功能与灰质萎缩和白色物质完整性之间的关系。采用基于体素的方法分析灰质和白色物质，我们专门研究了多发性硬化症参与者的更高水平的健康是否与保留的灰质体积和白色物质的完整性相关。我们发现心肺适应性和区域灰质体积以及较高的局灶性分数各向异性值之间存在正相关。统计映射显示，更高水平的健身与更大的灰质体积中线皮质结构，包括内侧额回，前扣带皮层和楔前叶。此外，我们还发现，健身水平的提高与左丘脑辐射和右前冠辐射的各向异性分数较高。保留的灰质体积和白质束完整性与处理速度测量的更好性能相关。两者合计，这些结果表明，健身发挥预防性的影响，早期观察到的脑萎缩，在多发性硬化症中保持神经元的完整性，从而减少长期残疾。
Alterations in gray and white matter have been well documented in individuals with multiple sclerosis. Severity and extent of such brain tissue damage have been associated with cognitive impairment, disease duration and neurological disability, making quantitative indices of tissue damage important markers of disease progression. In this study, we investigated the association between cardiorespiratory fitness and measures of gray matter atrophy and white matter integrity. Employing a voxel-based approach to analyses of gray matter and white matter, we specifically examined whether higher levels of fitness in multiple sclerosis participants were associated with preserved gray matter volume and integrity of white matter. We found a positive association between cardiorespiratory fitness and regional gray matter volumes and higher focal fractional anisotropy values. Statistical mapping revealed that higher levels of fitness were associated with greater gray matter volume in the midline cortical structures including the medial frontal gyrus, anterior cingulate cortex and the precuneus. Further, we also found increasing levels of fitness were associated with higher fractional anisotropy in the left thalamic radiation and right anterior corona radiata. Both preserved gray matter volume and white-matter tract integrity were associated with better performance on measures of processing speed. Taken together, these results suggest that fitness exerts a prophylactic influence on the cerebral atrophy observed early on preserving neuronal integrity in multiple sclerosis, thereby reducing long-term disability.
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