Nalbuphine could decrease the rewarding effect induced by tramadol in mice while enhancing its antinociceptive activity
Nalbuphine could decrease the rewarding effect induced by tramadol in mice while enhancing its antinociceptive activity
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DOI：
10.1016/j.ejphar.2015.03.062
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发表时间：
2015-07-05
影响因子：
5
通讯作者：
Barakat, Waleed
中科院分区：
文献类型：
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作者：
Abdel-Ghany, Rasha;Nabil, Mahmoud;Barakat, Waleed
纳布啡是一种κ阿片受体激动剂和μ阿片受体部分激动剂，已被用作镇痛剂或与吗啡一起用作佐剂，以减轻吗啡依赖和奖赏效应的发展。本研究探讨了纳布啡对曲马多奖赏效应和抗伤害作用的影响。使用小鼠中的条件性位置偏爱（CPP）范例，我们证明了纳布啡（7 mg/kg，s.c.）与曲马多（70 mg/kg，s.c.）完全阻断曲马多诱导的CPP。纳布啡联合给药阻断曲马多引起的丘脑背核多巴胺水平的增加。这些作用伴随着曲马多的抗伤害作用的增加而不是减弱。这些结果表明，纳布啡可能有很大的潜力作为曲马多滥用的药物治疗。(C)2015爱思唯尔B. V.保留所有权利。
Nalbuphine, a kappa-opioid agonist and mu-opioid partial agonist, has been used as an analgesic or an adjuvant with morphine to attenuate the development of morphine dependence and rewarding effect. In this study, we investigated the effect of nalbuphine on tramadol rewarding effect and antinociception. Using the conditioned place preference (CPP) paradigm in mice, we demonstrated that co-administration of nalbuphine (7 mg/kg, s.c.) with tramadol (70 mg/kg, s.c.) during conditioning completely blocked the CPP induced by tramadol. Co-administration of nalbuphine blocked the increase in dopamine level in the nucleus accumbens induced by tramadol. These actions were accompanied by an increase rather than attenuation of the antinociceptive effect of tramadol. These results suggest that nalbuphine could have a great potential as a pharmacotherapy for tramadol abuse. (C) 2015 Elsevier B.V. All rights reserved.