SURVIVAL OF MAMMALS BREATHING ORGANIC LIQUIDS EQUILIBRATED WITH OXYGEN AT ATMOSPHERIC PRESSURE
SURVIVAL OF MAMMALS BREATHING ORGANIC LIQUIDS EQUILIBRATED WITH OXYGEN AT ATMOSPHERIC PRESSURE
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DOI：
10.1126/science.152.3730.1755
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发表时间：
1966-01-01
期刊：
影响因子：
56.9
通讯作者：
GOLLAN, F
中科院分区：
文献类型：
--
作者：
CLARK, LC;GOLLAN, F
由于O2和CO2在某些硅油和氟碳液体中极易溶解，因此这些液体将支持哺乳动物的呼吸。吸入硅油的老鼠和猫在恢复呼吸空气后不久就会死亡，而吸入氟碳化合物的老鼠和猫则能存活数周。小鼠的呼吸最佳支持这些有机液体在约20[degree]C。在猫中，动脉氧合是极好的，但有一些损害的CO2消除。所有动物都因呼吸氟碳液体而遭受了一些肺部损伤。对有机液体呼吸的继续研究可能会导致开发一种安全的方法，以支持人类在大气压下通过与气体平衡的液体进行呼吸。
Because O2 and CO2 are very soluble in certain silicone oils and fluorocarbon liquids, these liquids will support respiration of mammals. Mice and cats respiring silicone oil die shortly after return to air breathing, while those breathing fluorocarbon survive for weeks. The respiration of mice is optimally supported by these organic liquids at about 20[degree]C. In cats, arterial oxygenation is excellent, but there is some impairment of CO2 elimination. All animals have suffered some pulmonary damage from breathing fluorocarbon liquids. Continued investigation of organic fluid respiration may lead to development of a safe method to support the respiration of man by liquids equilibrated with gases at atmospheric pressure.