Improved muscle activation using proximal nerve stimulation with subthreshold current pulses at kilohertz-frequency
Improved muscle activation using proximal nerve stimulation with subthreshold current pulses at kilohertz-frequency
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使用千赫兹频率的阈下电流脉冲刺激近端神经来改善肌肉激活
DOI：
10.1088/1741-2552/aab90f
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发表时间：
2018
影响因子：
4
通讯作者：
Xiaogang Hu
中科院分区：
文献类型：
--
作者：
Yang Zheng;Xiaogang Hu
Objective.经皮电神经刺激可以通过外部激活肌肉来帮助患有神经系统疾病的个体恢复运动功能。然而，传统的刺激技术往往会引起肌纤维的几乎同时招募，导致抽搐力的时间锁定的刺激。Approach.为了诱导手指屈肌肌肉的不太同步的激活，我们以10 kHz（脉冲宽度为80 µs）或7.14 kHz（脉冲宽度为120 µs）（高频模式，HF）的载波频率向正中神经和尺神经的近端节段递送了集群较窄的脉冲，并以30或40 Hz的频率递送了不同的集群脉冲。使用脉冲频率为30或40 Hz（低频模式，LF）的常规刺激进行比较。在HF和LF模式之间匹配的诱发肌肉力，力的变化，在手指屈肌记录的高密度肌电图（EMG）信号和刺激引起的疼痛水平进行了比较。主要结果。与LF模式相比，10 kHz HF模式下的复合动作电位显示出显著差异（即较低的幅度和面积，以及较宽的持续时间），表明消除的动作电位。在10 kHz模式中，诱发力的较小波动进一步证明了不同运动单元的同步激活较少。在7.14 kHz高频条件下，这些影响趋于减弱。然而，由于HF模式中使用的高电荷密度，HF模式中的痛觉水平未降低。我们的研究结果表明，不同的神经纤维招募异步通过总结不同数量的阈下去极化在HF模式。意义与LF模式相比，HF模式刺激能够以较不同步的方式激活神经纤维，这更类似于生理激活模式。
Objective. Transcutaneous electrical nerve stimulation can help individuals with neurological disorders to regain their motor function by activating muscles externally. However, conventional stimulation technique often induces near-simultaneous recruitment of muscle fibers, leading to twitch forces time-locked to the stimulation. Approach. To induce less synchronized activation of finger flexor muscles, we delivered clustered narrower pulses to the proximal segment of the median and ulnar nerves at a carrier frequency of either 10 kHz (with an 80 µs pulse width) or 7.14 kHz (with a 120 µs pulse width) (high-frequency mode, HF), and different clustered pulses were delivered at a frequency of 30 or 40 Hz. Conventional stimulation with pulse frequency of 30 or 40 Hz (low-frequency mode, LF) was used for comparison. With matched elicited muscle forces between the HF and LF modes, the force variation, the high-density electromyogram (EMG) signals recorded at the finger flexor muscles and stimulation-induced-pain levels were compared. Main results. The compound action potentials in the 10 kHz HF mode revealed a significant difference (i.e. a lower amplitude and area, and a wider duration) compared with the LF mode, indicating cancellations of asynchronized action potentials. A smaller fluctuation in the elicited forces in the 10 kHz mode further demonstrated the less synchronized activation of different motor units. These effects tended to be weaker in the 7.14 kHz HF condition. However, the levels of pain sensation was not reduced in the HF mode potentially due to the high charge density used in the HF mode. Our findings indicated that different nerve fibers were recruited asynchronously through summations of different numbers of subthreshold depolarizations in the HF mode. Significance. Compared with the LF mode, the HF mode stimulation was capable of activating the nerve fibers in a less synchronized way, which is more similar to the physiological activation pattern.
影响因子：
2.5
作者：
Yao, WX;Fuglevand, AJ;Enoka, RM
通讯作者：
Enoka, RM
影响因子：
4.6
作者：
Gerasimenko, Yury;Gorodnichev, Ruslan;Moshonkina, Tatiana;Sayenko, Dimitry;Gad, Parag;Edgerton, V. Reggie
通讯作者：
Edgerton, V. Reggie