Linking Cholinergic Interneurons, Synaptic Plasticity, and Behavior during the Extinction of a Cocaine-Context Association.
Linking Cholinergic Interneurons, Synaptic Plasticity, and Behavior during the Extinction of a Cocaine-Context Association.
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DOI：
10.1016/j.neuron.2016.05.001
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发表时间：
2016-06-01
期刊：
影响因子：
16.2
通讯作者：
Witten IB
中科院分区：
文献类型：
--
作者：
Lee J;Finkelstein J;Choi JY;Witten IB
尽管事实上，胆碱能中间神经元是一个关键的细胞类型内的核突触可塑性和胆碱能中间神经元的体内活性之间的关系仍有待建立。在这里，我们确定了三种方式之间的联系，胆碱能中间神经元的活动，突触可塑性，并在小鼠的学习经历的可卡因上下文协会灭绝。我们发现，胆碱能中间神经元的活动调节可卡因上下文关联的消退学习，并产生持续减少到中等多刺神经元的多巴胺能突触前强度。有趣的是，胆碱能中间神经元的激活本身并不支持强化学习，也不支持可塑性，这表明这些神经元具有调节功能而不是强化功能。
Despite the fact that cholinergic interneurons are a key cell-type within the nucleus accumbens, a relationship between synaptic plasticity and the in vivo activity of cholinergic interneurons remains to be established. Here, we identify a three-way link between the activity of cholinergic interneurons, synaptic plasticity, and learning in mice undergoing the extinction of a cocaine-context association. We found that activity of cholinergic interneurons regulates extinction learning for a cocaine-context association and generates a sustained reduction in glutamatergic presynaptic strength onto medium spiny neurons. Interestingly, activation of cholinergic interneurons does not support reinforcement learning nor plasticity by itself, suggesting that these neurons have a modulatory rather than a reinforcing function.