Cucurbitacins - A Promising Target for Cancer Therapy
Cucurbitacins - A Promising Target for Cancer Therapy
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DOI：
10.12816/0006025
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发表时间：
2013-01-01
影响因子：
2
通讯作者：
Alghasham, Abdullah A.
中科院分区：
文献类型：
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作者：
Alghasham, Abdullah A.
在过去的几十年中，大量的葫芦素已经从葫芦科以外的其他植物科的各种植物物种中分离出来。虽然这些葫芦科植物的根和果实非常苦，但由于其广泛的药理活性，如抗炎和抗癌作用，它们已在一些国家被用作民间药物。在过去的十年中，葫芦素已被证明可以抑制增殖和诱导凋亡，利用一系列的体外和体内癌细胞模型。葫芦素的作用靶点包括纤维肌动蛋白、信号转导和转录激活因子（STAT）、环氧合酶-2（COX-2）等。本文综述了葫芦素类化合物的天然来源、化学结构和衍生物、物理性质、生物活性及其抑制肿瘤细胞增殖的机制。这扩大了我们对付一种我们未能面对的毁灭性疾病的军备。
During the last decades a large number of cucurbitacins have been isolated from various plant species belonging to other plant families than Cucurbitaceae. Although the roots and the fruits of plant belong to these Cucurbitaceae species are very bitter, they have been used as folk medicines in some countries because of their wide spectrum of pharmacological activities such as anti-inflammation and anticancer effects. In the last ten years, cucurbitacins had been shown to inhibit proliferation and induced apoptosis utilizing a long array of in vitro and in vivo cancer cell models. Several molecular targets for cucurbitacins have been discovered, such as fibrous-actin, signal transducer and activator of transcription (STAT), cyclooxygenase-2, etc. This review aimed at elucidating the natural sources of some cucurbitacin compounds, their chemical structure and derivatives, physical properties, biological activities and mechanism by which they reduce the proliferation human cancer cells. This widens our armaments against a devastating disease that we are failing to face.