The effect of a very short interpregnancy interval and pregnancy outcomes following a previous pregnancy loss.
The effect of a very short interpregnancy interval and pregnancy outcomes following a previous pregnancy loss.
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DOI：
10.1016/j.ajog.2014.09.020
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发表时间：
2015-03
影响因子：
9.8
通讯作者：
Schisterman, Enrique F.
中科院分区：
文献类型：
--
作者：
Wong, Luchin F.;Schliep, Karen C.;Silver, Robert M.;Mumford, Sunni L.;Perkins, Neil J.;Ye, Aijun;Galai, Noya;Wactawski-Wende, Jean;Lynch, Anne M.;Townsend, Janet M.;Faraggi, David;Schisterman, Enrique F.
我们试图评估妊娠丢失后短解释间隔（IPI）与随后的活产和妊娠结局之间的关系。对入组阿司匹林对妊娠和生殖的影响试验的hCG阳性妊娠试验女性进行了次要分析，其末次生殖结局为流产（n=677）。IPI定义为末次妊娠流产与当前妊娠末次月经之间的时间，并按3个月间隔分类。妊娠结局包括活产、流产和任何妊娠并发症。采用Poisson回归的多变量相对危险度估计对IPI组进行比较。IPI组之间的人口统计学特征相似。既往流产的平均孕龄为8.6 ± 2.8周。总体活产率为76.5%，IPI ≤ 3个月与IPI> 3个月的活产率相似，aRR=1.07（95%CI 0.98-1.16）。与IPI > 3个月的患者相比，IPI ≤ 3个月的患者的围着床期流产（aRR = 0.95; 95% CI 0.51 - 1.80）、临床确认流产（aRR=0.75; 95% CI 0.51-1.10）和任何妊娠并发症（aRR=0.88; 95% CI 0.71-1.09）的发生率也相似。活产率和不良妊娠结局（包括妊娠丢失）与既往妊娠丢失后的极短IPI无关。传统的建议是在怀孕失败后至少等待3个月再尝试新的怀孕可能是不必要的。
We sought to assess the relationship between a short interpregnancy interval (IPI) following a pregnancy loss and subsequent live birth and pregnancy outcomes. A secondary analysis of women enrolled in the Effects of Aspirin in Gestation and Reproduction trial with an hCG-positive pregnancy test and whose last reproductive outcome was a loss were included in this analysis (n=677). IPI was defined as the time between last pregnancy loss and last menstrual period of the current pregnancy and categorized by 3-month intervals. Pregnancy outcomes include live birth, pregnancy loss, and any pregnancy complications. These were compared between IPI groups using multivariate relative risk estimation by Poisson regression. Demographic characteristics were similar between IPI groups. The mean gestational age of prior pregnancy loss was 8.6 ± 2.8 weeks. The overall live birth rate was 76.5%, with similar live birth rates between those with IPI ≤ 3 months as compared to IPI > 3 months, aRR=1.07 (95% CI 0.98–1.16). Rates were also similar for peri-implantation loss (aRR=0.95; 95% CI 0.51–1.80), clinically confirmed loss, (aRR=0.75; 95% CI 0.51–1.10), and any pregnancy complication (aRR=0.88; 95% CI 0.71–1.09) for those with IPI ≤ 3 months as compared to IPI > 3 months. Live birth rates and adverse pregnancy outcomes, including pregnancy loss, were not associated with a very short IPI after a prior pregnancy loss. The traditional recommendation to wait at least 3 months after a pregnancy loss before attempting a new pregnancy may not be warranted.
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DOI：
10.1136/bmj.c3967
发表时间：
2010-08-05
期刊：
BMJ (Clinical research ed.)
影响因子：
--
作者：
Love ER;Bhattacharya S;Smith NC;Bhattacharya S
通讯作者：
Bhattacharya S
DOI：
10.1016/j.ijgo.2004.08.003
发表时间：
2005-04-01
影响因子：
3.8
作者：
Conde-Agudelo, A;Belizán, JM;Rosas-Bermudez, A
通讯作者：
Rosas-Bermudez, A
影响因子：
2.6
作者：
El Behery, Manal M.;Siam, Soha;Ibrahim, Zakia M.
通讯作者：
Ibrahim, Zakia M.
DOI：
10.3109/01674829609025678
发表时间：
1996-09-01
影响因子：
3.1
作者：
Cuisinier, M;Janssen, H;Hoogduin, C
通讯作者：
Hoogduin, C
影响因子：
158.5
作者：
WILCOX, AJ;WEINBERG, CR;NISULA, BC
通讯作者：
NISULA, BC