CAFFEINE AND CEREBRAL BLOOD-FLOW
CAFFEINE AND CEREBRAL BLOOD-FLOW
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DOI：
10.1192/bjp.143.6.604
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发表时间：
1983-01-01
影响因子：
10.5
通讯作者：
WEINMAN, ML
中科院分区：
文献类型：
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作者：
MATHEW, RJ;BARR, DL;WEINMAN, ML
用133 μ l吸入法测定两组正常志愿者口服咖啡因250或500 mg前后30 min的局部脑血流量（rCBF）。在相同的实验室条件下，以相似的间隔在第3组受试者中测量两次rCBF。接受咖啡因的受试者显示rCBF显著降低，而其他受试者从第一次到第二次测量没有显示rCBF变化。2个咖啡因组在rCBF降低程度上没有差异。咖啡因后脑血流量减少没有区域差异。3组患者的潮气末CO、脉率、血压、额部皮肤温度和呼吸频率均无显著变化。
Two groups of normal volunteers had regional cerebral blood flow (rCBF) measured, by the 133Xe inhalation technique, before and 30 min after 250 or 500 mg caffeine give orally. rCBF was measured in a 3rd group of subjects, twice at a similar interval under identical laboratory conditions. Subjects who received caffeine showed significant decreases in rCBF while the others showed no rCBF change from the 1st to the 2nd measurement. The 2 caffeine groups did not differ in degrees of rCBF reduction. There were no regional variations in the post-caffeine decrease in cerebral blood flow. The 3 groups did not show significant changes in end-tidal CO, pulse rate, blood pressure, forehead skin temperature and respiratory rate.