Changes in the effects of interleukin-1β and tumor necrosis factor-α on platelet activation in early pregnancy
Changes in the effects of interleukin-1β and tumor necrosis factor-α on platelet activation in early pregnancy
复制标题
DOI：
10.1080/09537100120104872
复制
发表时间：
2001-12-01
期刊：
影响因子：
3.3
通讯作者：
Sullivan, MHF
中科院分区：
文献类型：
--
作者：
Bar, J;Zosmer, A;Sullivan, MHF
已知血小板在正常妊娠中被激活，并且在病理性妊娠状态如先兆子痫中被进一步激活。控制血小板活化的因素尚不清楚，但细胞因子，如白细胞介素1 β（IL-1 β）和肿瘤坏死因子-α（TNF-α）已被发现影响血小板功能，并被认为与早孕有关。我们评估了这些细胞因子对妊娠不同阶段妇女血小板的影响。我们比较了两种方法：血小板体外聚集的聚集测定法和血小板P-选择素表达的流式细胞术。IL-1 β和TNF-α对妊娠早期妇女血小板的体外聚集和P-选择素表达没有影响，而对妊娠晚期的抑制作用。我们得出结论，母体血小板功能在整个怀孕期间发生了显着的变化。
Platelets are known to be activated in normal pregnancy, and are further activated in pathological pregnancy states, such as preeclampsia. The factors controlling platelet activation are unknown, but cytokines, such as interleukin 1 beta (IL-1 beta) and tumor necrosis-alpha (TNF-alpha) have been found to affect platelet function and are believed to be involved in early pregnancy. We assessed the effects of these cytokines on platelets from women at various stages of pregnancy. We compared two methods: platelet in vitro aggregation by aggregometry, and platelet P-selectin expression by flow cytometry. IL-1 beta and TNF-alpha had no effect on the in vitro aggregation and P-selectin expression of platelets from women in the first trimester of pregnancy as compared to the inhibitory effects of both in late pregnancy. We conclude that maternal platelet function undergoes a marked change throughout pregnancy.