Astaxanthin limits exercise-induced skeletal and cardiac muscle damage in mice
Astaxanthin limits exercise-induced skeletal and cardiac muscle damage in mice
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DOI：
10.1089/152308603321223630
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发表时间：
2003-02-01
影响因子：
6.6
通讯作者：
Yoshikawa, T
中科院分区：
文献类型：
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作者：
Aoi, W;Naito, Y;Yoshikawa, T
饮食中的抗氧化剂可以减轻剧烈运动对各种组织的氧化损伤。抗氧化剂虾青素的有益效果已在体外得到证实，但尚未在体内得到证实。我们研究了膳食中添加虾青素对剧烈运动引起的小鼠腓肠肌和心脏氧化损伤的影响。将C57 BL/6小鼠（7周龄）分成组：休息对照组、剧烈运动组和补充有虾青素的运动组。经过3周的运动适应后，两个运动组都在跑步机上以28 m/min的速度跑步，直到筋疲力尽。在虾红素组中，腓肠肌和心脏中的4-羟基-2-壬烯醛修饰蛋白和8-羟基-2 '-脱氧鸟苷的代谢增加被钝化。增加血浆肌酸激酶活性，并在腓肠肌和心脏髓过氧化物酶活性，也减少了虾青素。从3周补充开始，虾青素显示在腓肠肌和心脏中积累。虾青素可以减轻运动引起的小鼠骨骼肌和心脏损伤，包括相关的中性粒细胞浸润，诱导进一步的损伤。
Dietary antioxidants may attenuate oxidative damage from strenuous exercise in various tissues. Beneficial effects of the antioxidant astaxanthin have been demonstrated in vitro, but not yet in vivo. We investigated the effect of dietary supplementation with astaxanthin on oxidative damage induced by strenuous exercise in mouse gastrocnemius and heart. C57BL/6 mice (7 weeks old) were divided into groups: rested control, intense exercise, and exercise with astaxanthin supplementation. After 3 weeks of exercise acclimation, both exercise groups ran on a treadmill at 28 m/min until exhaustion. Exercise-increased 4-hydroxy-2-nonenal-modified protein and 8-hydroxy-2'-deoxyguanosine in gastrocnemius and heart were blunted in the astaxanthin group. Increases in plasma creatine kinase activity, and in myeloperoxidase activity in gastrocnemius and heart, also were lessened by astaxanthin. Astaxanthin showed accumulation in gastrocnemius and heart from the 3 week supplementation. Astaxanthin can attenuate exercise-induced damage in mouse skeletal muscle and heart, including an associated neutrophil infiltration that induces further damage.