CISPLATIN NEPHROTOXICITY - INSIGHTS INTO MECHANISM
CISPLATIN NEPHROTOXICITY - INSIGHTS INTO MECHANISM
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DOI：
10.1111/j.1365-2605.1987.tb00200.x
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发表时间：
1987-02-01
影响因子：
--
通讯作者：
GUTTENPLAN, J
中科院分区：
文献类型：
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作者：
SAFIRSTEIN, R;WINSTON, J;GUTTENPLAN, J
顺式二氯二胺铂（II），或顺铂，是目前在癌症化疗中应用最广泛的药物之一。其更大功效的主要限制是其肾毒性。顺铂的急性和慢性肾毒性在人和动物中发生，特别是在反复给药后。形态学损伤局限于近端小管P3段。异常的水和溶质回收和经肾小球的液体通道通常与顺铂肾毒性有关。肾脏对顺铂的易感性可能与其作为铂的主要排泄器官的功能有关。铂与多种细胞器和大分子结合，但其细胞毒性的确切机制尚不清楚。由于肾功能异常前有一段大体肾功能正常的时期，因此它是研究金属致急性肾功能衰竭早期生理生化决定因素的理想模型。
Cis‐dichlorodiammine platinum (II), or cisplatin, is currently among the most widely used agents in the chemotherapy of cancer. The chief limit to its greater efficacy is its nephrotoxicity. Acute and chronic nephrotoxicity of cisplatin occurs in man and animals especially after repeated administration. Morphological damage is restricted to the P3 segment of the proximal tubule. Abnormalities of water and solute reclamation and transglomerular passage of fluid are commonly associated with cisplatin nephrotoxicity. The vulnerability of the kidney to cisplatin may be related to its function as the primary excretory organ for platinum. Platinum binds to multiple cellular organelles and macromolecules, yet the precise mechanism of its cytotoxicity has not been delineated. Because abnormalities in renal function are preceded by a period where gross renal function appears normal, it is an ideal model to study the early physiological and biochemical determinants of metal induced acute renal failure.