Golden age of insecticide research: Past, present, or future?
Golden age of insecticide research: Past, present, or future?
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DOI：
10.1146/annurev.ento.43.1.1
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发表时间：
1998-01-01
影响因子：
23.8
通讯作者：
Quistad, GB
中科院分区：
文献类型：
--
作者：
Casida, JE;Quistad, GB
大约 50 年前，杀虫剂研究在防治害虫方面取得了第一次“彻底”胜利，其中使用的是氯化烃，随后有机磷酸酯、氨基甲酸甲酯和拟除虫菊酯——所有这些神经活性化学物质也紧随其后。这个发现的黄金时代是我们目前大多数杀虫剂的来源。接下来的挑战变成了健康和环境，黄金时代遇到了选择性和可降解的化合物。接下来的重点转向抗性、新的生化目标和害虫防治的新化学方法。当前基因工程的黄金时代已经减少但不太可能消除主要农作物上的化学物质使用。杀虫剂研究经历了几个黄金时代，现在正处于将化学品和生物制剂相结合的复兴时期，以实现可持续害虫控制和人类安全。
Insecticide research led to the first "complete" victories in combatting pests almost 50 years ago with the chlorinated hydrocarbons followed quickly by the organophosphates, methylcarbamates, and pyrethroids-all neuroactive chemicals. This Golden Age of Discovery was the source of most of our current insecticides. The challenge then became health and the environment, a Golden Age met with selective and degradable compounds. Next the focus shifted to resistance, novel biochemical targets, and new chemical approaches for pest control. The current Golden Age of Genetic Engineering has curtailed, but is unlikely to eliminate, chemical use on major crops. Insecticide research, having passed through several Golden Ages, is now in a renaissance of integrating chemicals and biologicals for sustainable pest control with human safety.