RELATIONSHIP BETWEEN ABSORPTION OF RADIOLABELED SOLUBLE INSULIN, SUBCUTANEOUS BLOOD-FLOW, AND ANTHROPOMETRY
RELATIONSHIP BETWEEN ABSORPTION OF RADIOLABELED SOLUBLE INSULIN, SUBCUTANEOUS BLOOD-FLOW, AND ANTHROPOMETRY
复制标题
DOI：
10.2337/diacare.15.11.1484
复制
发表时间：
1992-11-01
期刊：
影响因子：
16.2
通讯作者：
OWENS, DR
中科院分区：
文献类型：
--
作者：
VORA, JP;BURCH, A;OWENS, DR
目的评价12名正常人对研究设计和方法的吸收率之间的相互关系（年龄范围23-30岁，BMI 18.2 - 41.3 kg/m2），同时评估I-125标记的可溶性胰岛素和SCBF的吸收在不同的研究日，对前腹壁、前大腿中部和上臂部位进行（Tc-99 m清除率）。在两个不同的场合以随机顺序检查每个部位。通过注射后6 h外部监测注射部位的残留放射性水平，测定I-125可溶性胰岛素的吸收。使用双参数和三参数双指数模型描述残留放射性水平-时间曲线，包括可溶性胰岛素缓慢吸收的特征早期（滞后期）。测量包括体重指数（BMI）、皮下脂肪组织层超声测量、前腹壁、肱二头肌、肱三头肌、股中前部和肩胛下部位的卡尺皮褶厚度。结果I-125可溶性胰岛素吸收率与SCBF呈高度显著正相关（r（S）= 0.44-0.52; P < 0.010）。001）。滞后相持续时间与SCBF呈负相关（r（s）= -0.34--0.51; P < 0.01-0.001）。肥胖程度与可溶性胰岛素吸收率（r（s）= -0.43--0.71; P < 0.001）和SCBF（r（s）= -0.27--0.62; P < 0.05-0.001）呈负相关。腹部注射部位的滞后期明显短于大腿和手臂注射部位（P < 0.05-0.01）。结论：可溶性胰岛素的吸收率（包括滞后期）与SCBF呈正相关。增加肥胖会缩短早期滞后期的持续时间，并降低可溶性胰岛素和SCBF的吸收率。
OBJECTIVE To evaluate the interrelationships between the rate of absorption ofRESEARCH DESIGN AND METHODS In 12 normal men (age range 23-30 yr, BMI 18.2 - 41.3 kg/m2), simultaneous assessment of the absorption of I-125-labeled soluble insulin and SCBF (Tc-99m clearance) was performed, on separate study days, for the anterior abdominal wall, anterior midthigh, and the upper arm sites. Each site was examined in a randomized order on two separate occasions. Absorption of I-125-soluble insulin was determined by external monitoring of residual radioactivity levels at the injection site for 6 h postinjection. Residual radioactivity level-time curves, including the characteristic early phase of slow absorption of soluble insulin (the lag phase), were described using two - and three- parameter biexponential models. Anthropometric measurements included BMI, ultrasonic measurement of the subcutaneous adipose tissue layer, and caliper skin fold thickness at the anterior abdominal wall, biceps, triceps, anterior midthigh, and subscapular sites.RESULTS A highly significant positive relationship was observed between the rate of absorption of I-125-soluble insulin and SCBF (r(S) = 0.44-0.52; P < 0.010. 001). The duration of the lag phase was inversely correlated with SCBF (r(s) = -0.34--0.51; P < 0.01-0.001). Inverse relationships also were observed for the subjects' degree of adiposity with the rate of soluble insulin absorption (r(s) = -0.43--0.71; P < 0.001) and SCBF (r(s) = -0.27--0.62; P < 0.05-0.001). Significantly shorter lag phase was observed for the abdominal site compared with thigh and arm injection sites (P < 0.05-0.01).CONCLUSIONS The rate of absorption of soluble insulin, including during the lag phase, is positively correlated with SCBF. Increasing adiposity prolongs the duration of the early lag phase and reduces the rate of absorption of soluble insulin and SCBF.