Logarithmic transformation of spectral-domain optical coherence tomography data in uveitis-associated macular edema.
Logarithmic transformation of spectral-domain optical coherence tomography data in uveitis-associated macular edema.
复制标题
葡萄膜炎相关黄斑水肿的谱域光学相干断层扫描数据的对数变换。
DOI：
10.1167/iovs.11-8193
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发表时间：
2011
影响因子：
4.4
通讯作者：
Yeh,Steven
中科院分区：
文献类型：
--
作者：
Payne,JohnF;Bruce,BeauB;Lee,LyndonBK;Yeh,Steven
目的：确定谱域光学相干断层扫描（logSD-OCT）视网膜厚度数据的对数变换用于评估葡萄膜炎相关黄斑水肿的临床有意义的变化的效用。我们确定了2010年8月至2011年3月在我们机构发生的非感染性葡萄膜炎相关黄斑水肿患者。仅纳入SD-OCT成像的患者。记录临床诊断、视力和中央亚视野厚度（CST）测量值。对视网膜厚度进行对数变换并绘制频率直方图。建立对数最小分辨率角（logMAR）视力的线性混合效应模型，以解释访视和眼间的患者内相关性。结果：共分析了34例患者的98张SD-OCT图像。检查时的平均年龄为40岁（范围：11-69岁）。解剖学诊断包括前/中间葡萄膜炎（23%）、中间葡萄膜炎（21%）、后葡萄膜炎（12%）和全葡萄膜炎（44%）。LogSD-OCT数据提供了比标准CST更正态的分布。CST数据的偏度和峰度分别为1.04和0.37，logSD-OCT数据的偏度和峰度分别为0.40和-0.48。logSD-OCT与logMAR视力之间呈正相关。具体而言，logSD-OCT每增加0.1单位，logMAR视力增加（恶化）0.082单位（95% CI：0.057-0.107，P< 0.001）。SD-OCT测量值的对数转换提供了更正态的分布，并与logMAR视力呈正相关。视网膜厚度的这种转变对于在未来的葡萄膜炎研究中评估SD-OCT测量的临床显著变化可能是有价值的。
Purpose.: To determine the utility of logarithmic transformation of spectral-domain optical coherence tomography (logSD-OCT) retinal thickness data for assessment of clinically meaningful changes in uveitis-associated macular edema.Methods.: Patients with noninfectious uveitis-associated macular edema at our institution between August 2010 and March 2011 were identified. Only those with SD-OCT imaging were included. The clinical diagnoses, visual acuities, and central subfield thickness (CST) measurements were recorded. Logarithmic transformation of the retinal thickness was performed and frequency histograms plotted. A linear mixed-effects model of the logarithm minimum angle of resolution (logMAR) visual acuity on logSD-OCT was created to account for within-patient correlation among visits and between eyes.Results.: A total of 98 SD-OCT images from 34 patients were analyzed. The mean age at examination was 40 years (range, 11–69 years). Anatomic diagnoses included anterior/intermediate uveitis (23%), intermediate uveitis (21%), posterior uveitis (12%), and panuveitis (44%). LogSD-OCT data provided a more normal distribution than standard CST. Skewness and kurtosis of CST data were 1.04 and 0.37, respectively, and skewness and kurtosis of logSD-OCT data were 0.40 and− 0.48, respectively. There was a positive correlation between logSD-OCT and logMAR visual acuity. Specifically, for each 0.1-unit increase in logSD-OCT, the logMAR visual acuities increased (worsened) by 0.082 units (95% CI: 0.057–0.107, P< 0.001).Conclusions.: Logarithmic transformation of SD-OCT measurements provided a more normal distribution and positively correlated with logMAR visual acuity. This transformation of retinal thickness may be valuable for assessing clinically significant changes in SD-OCT measurements in future uveitis studies.