A new approach for the validation of skeletal muscle modelling using MRI data
A new approach for the validation of skeletal muscle modelling using MRI data
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DOI：
10.1007/s00466-010-0567-0
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发表时间：
2011-05-01
影响因子：
4.1
通讯作者：
Kober, Cornelia
中科院分区：
文献类型：
--
作者：
Boel, Markus;Sturmat, Maike;Kober, Cornelia
骨骼肌的主动和被动实验通常安排在孤立的肌肉或考虑整个肌肉包，如手臂或腿。这两种方法都有优点和缺点。通过对分离的肌肉进行实验，结果表明，没有考虑有关周围组织的信息，这导致分离的肌肉的规格不足。特别是包埋肌的肌肉形态和肌纤维方向与离体肌完全不同。相比之下，一个明显的优势是可以以独特的、孤立的方式研究机械特性。另一方面，通过对肌肉包进行实验，上述优点和缺点发生了逆转。在这种情况下，整个周围组织被认为是肌肉的机械特性，这是更难以识别。然而，嵌入的肌肉反映了一个更现实的情况，在孤立的条件。因此，在我们所知的拟议工作中，我们首次提出了一种技术，该技术允许研究肌肉包内单个骨骼肌的特性，而无需对感兴趣的肌肉周围的组织进行任何计算。在这样做时，我们使用上臂在收缩期间的磁共振成像数据。通过应用三维连续本构肌肉模型，我们能够研究上臂内的肱二头肌，并通过光学实验验证建模方法。
Active and passive experiments on skeletal muscles are in general arranged on isolated muscles or by consideration of the whole muscle packages, such as the arm or the leg. Both methods exhibit advantages and disadvantages. By applying experiments on isolated muscles it turns out that no information about the surrounding tissues are considered what leads to insufficient specifications of the isolated muscle. Especially, the muscle shape and the fibre directions of an embedded muscle are completely different to that of the same isolated muscle. An explicit advantage, in contrast, is the possibility to study the mechanical characteristics in an unique, isolated way. On the other hand, by applying experiments on muscle packages the aforementioned pros and cons reverse. In such situation, the whole surrounding tissue is considered in the mechanical characteristics of the muscle which are much more difficult to identify. However, an embedded muscle reflects a much more realistic situation as in isolated condition. Thus, in the proposed work to our knowledge, we, for the first time, suggest a technique that allows to study characteristics of single skeletal muscles inside a muscle package without any computation of the tissue around the muscle of interest. In doing so, we use magnetic resonance imaging data of an upper arm during contraction. By applying a three-dimensional continuum constitutive muscle model we are able to study the biceps brachii inside the upper arm and validate the modelling approach by optical experiments.