Cellular Basis of Bronchial Inflammation in Chronic Obstructive Pulmonary Disease(COPD)
Cellular Basis of Bronchial Inflammation in Chronic Obstructive Pulmonary Disease(COPD)
复制标题
慢性阻塞性肺疾病（COPD）支气管炎症的细胞基础
DOI：
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发表时间：
2013
期刊：
影响因子：
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通讯作者：
A. Stoian
中科院分区：
文献类型：
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作者：
F. Petrescu;V. Biciușcă;O. I. Petrescu;I. Petrescu;Simona Coşoveanu;Daniela Marinescu;A. Stoian
慢性阻塞性肺疾病（COPD）是一个主要的健康问题，其特征是肺功能的进行性和不可逆的变化。这与慢性气道炎症、结构重塑和肺泡壁破坏有关。炎性细胞可能导致粘液分泌过多，通过蛋白酶、细胞因子和纤维化或促有丝分裂生长因子的分泌导致气道重塑。许多研究表明，中性粒细胞、巨噬细胞和T细胞在气道慢性炎症过程中发挥作用。识别危险因素、炎症介质并了解它们的相互作用对于开发抗炎治疗是重要的，抗炎治疗可以减少炎症并缓解COPD的临床症状。
Chronic obstructive pulmonary disease (COPD) is a major health problem, characterized by a progressively and irreversible change in lung function. This is associated with chronic airways inflammation, structural remodeling, and alveolar wall destruction. Inflammatory cells may contribute to mucus hypersecretion, the airways remodeling by the secretion of proteases, cytokines, and fibrotic or mitogenic growth factors. Neutrophils, macrophages, and T cells have implicated in many studies, indicating their roles in the chronic inflammatory process of airways. The identification of risk factors, inflammatory mediators, and understanding their interactions are important for the development of anti-inflammatory treatments, that may reduce the inflammation and alleviate the clinical symptoms of COPD.
小气道病理学与切除的人肺中 III 相的闭合能力增加和异常斜率有关。
DOI：
10.1164/arrd.1980.121.3.449
发表时间：
1980
期刊：
The American review of respiratory disease
影响因子：
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作者：
Petty,TL;Silvers,GW;Stanford,RE;Baird,MD;Mitchell,RS
通讯作者：
Mitchell,RS