Basic symptoms and psychotic symptoms: Their relationships in the at risk mental states, first episode and multi-episode schizophrenia
Basic symptoms and psychotic symptoms: Their relationships in the at risk mental states, first episode and multi-episode schizophrenia
复制标题
DOI：
10.1016/j.comppsych.2014.01.006
复制
发表时间：
2014-05-01
影响因子：
7.3
通讯作者：
Girardi, Paolo
中科院分区：
文献类型：
--
作者：
Comparelli, Anna;De Carolis, Antonella;Girardi, Paolo
在早期精神病领域，两种主要的方法试图开发评定工具，一种是调查基本症状域，另一种是减弱的精神病症状。为探讨精神病性疾病不同阶段基本症状（BS）与其他症状域的关系，选取32例超高危（UHR）、49例首发精神分裂症（FES）、42例多发精神分裂症（MES）和28例广泛性焦虑症（GAD）患者为研究对象。使用SIPS/SOPS和FCQ量表对参与者进行评估。采用协方差分析比较FCQ和SOPS评分，其中考虑了组间显著差异的社会人口统计学和临床变量。最后对精神分裂症谱系组进行FCQ和SOPS主成分分析。与GAD对照组相比，UHR、FES和MES组的SOPS评分较高。与GAD组相比，FES和MES组有更多的基本症状，而UHR与对照组没有差异。在广泛性焦虑症组中，BS和精神病性症状之间的相关性最大。根据主成分分析法提取出5个因子，其中BS加载在唯一的因子上。我们的研究结果意味着，精神病和非精神病之间的界限不能概述的基础上存在/不存在的基本和精神病性症状。(C)2014 Elsevier Inc. All rights reserved.
In the field of the early psychosis two main approaches attempt to develop rating tools, one investigating the basic symptoms domain, and the other the attenuated psychotic symptoms. To explore the relationship between basic symptoms (BSs) and other symptom domains in different phases of the psychotic illness 32 at ultra-high risk (UHR), 49 first episode schizophrenia (FES), 42 multiple episode schizophrenia (MES), and 28 generalized anxiety disorder (GAD) patients were enrolled. Participants were assessed using the SIPS/SOPS and the FCQ scales. Analyses of covariance taking into account socio-demographic and clinical variables significantly different between groups were applied to compare FCQ and SOPS scores. Finally FCQ and SOPS principal component analysis was carried out in the schizophrenia spectrum group. SOPS scores were higher in the UHR, FES and MES groups compared to the GAD control group. Concordantly, FES and MES groups had a higher number of basic symptoms in comparison with the GAD group, whereas UHR did not differ from the control group. The largest number of correlations between BSs and psychotic symptoms was found in the GAD group. According to the principal component analysis (PCA) five factors were extracted, with the BSs loading on a unique factor. Our findings imply that the boundary between psychotic and non-psychotic conditions cannot be outlined on the basis of the presence/absence of basic and psychotic symptoms. (C) 2014 Elsevier Inc. All rights reserved.