Extreme Sleep Durations and Increased C-Reactive Protein: Effects of Sex and Ethnoracial Group
Extreme Sleep Durations and Increased C-Reactive Protein: Effects of Sex and Ethnoracial Group
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DOI：
10.5665/sleep.2646
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发表时间：
2013-05-01
期刊：
影响因子：
5.6
通讯作者：
Jean-Louis, Girardin
中科院分区：
文献类型：
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作者：
Grandner, Michael A.;Buxton, Orfeu M.;Jean-Louis, Girardin
研究目的：我们假设极端的睡眠时间与c反应蛋白（CRP）升高有关，c反应蛋白是心血管疾病风险的促炎标志物。设计:横断面。设置：基于人群的研究。参与者：2007-2008年全国健康和营养调查参与者的全国代表性样本（n = 5,587名成年人）。干预措施:没有。测量和结果：研究了CRP与自我报告的总睡眠时间（TST）之间的关系。解释模型考虑了性别、年龄、种族/民族、体重指数（BMI）和BMI平方（BMI2）的影响。模型还探讨了失眠症状、睡眠呼吸暂停、主动医学疾病和降糖/降压治疗的作用。使用相互作用和分层分析来检查种族/族裔群体之间的差异模式。采用多项式和多项回归模型（< 5、5、6、7、8、9和bbb9 h）评估CRP与TST之间的非线性关系。线性项和平方项在所有模型中都是显著的，在性别和种族群体中有显著差异。总体而言，在调整了社会人口统计学和BMI的模型中，在非西班牙裔白人（CRP升高< 5小时和bbbb9小时）、黑人/非裔美国人（CRP升高< 5小时和8小时）、西班牙裔/拉丁裔（CRP升高< 5小时和8小时）和亚洲/其他（9小时和bbbb9小时较高，5小时和6小时较低）组中观察到不同的模式。种族群体也表现出按性别划分的模式。结论：在美国成年人的代表性样本中，CRP升高与极端睡眠时间有关。性别、种族/民族、睡眠障碍和医疗合并症影响这些关联。在未来关于影响心脏代谢疾病风险的睡眠相关差异的研究中，应考虑CRP在这些方面的差异。
Study Objectives: We hypothesize that extremes of sleep duration are associated with elevated C-reactive protein (CRP), a pro-inflammatory marker for cardiovascular disease risk.Design: Cross-sectional.Setting: Population-based research.Participants: Nationally representative sample of 2007-2008 National Health and Nutrition Examination Survey participants (n = 5,587 adults).Interventions: None.Measurements and Results: Associations between CRP and self-reported total sleep time (TST) were examined. Explanatory models considered contributions of sex, age, race/ethnicity, body mass index (BMI), and BMI squared (BMI2). Models also explored the role of insomnia symptoms, sleep apnea, active medical illness, and antidiabetic/antihypertensive treatment. Differential patterns among race/ethnicity groups were examined using interactions and stratified analyses. Nonlinear relationships between CRP and TST were assessed using polynomial and multinomial regression models (< 5, 5, 6, 7, 8, 9, and > 9 h). Linear and squared terms were significant in all models in the complete sample, with notable differences by sex and ethnoracial group. Overall, in models adjusted for sociodemographics and BMI, different patterns were observed for non-Hispanic white (elevated CRP for < 5 h and > 9 h), black/African-American (elevated CRP for < 5 h and 8 h), Hispanic/Latino (elevated CRP for > 9 h), and Asian/Other (higher in 9 and > 9 h and lower in 5 h and 6 h) groups. Ethnoracial groups also demonstrated patterning by sex.Conclusion: In a representative sample of American adults, elevated CRP was associated with extreme sleep durations. Sex, race/ethnicity, sleep disorders, and medical comorbidity influenced these associations. Differences in CRP along these dimensions should be considered in future research on sleep related disparities influencing cardiometabolic disease risk.