Age-related trends of gastritis and intestinal metaplasia in gastric carcinoma patients and in controls representing the population at large.
Age-related trends of gastritis and intestinal metaplasia in gastric carcinoma patients and in controls representing the population at large.
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DOI：
10.1038/bjc.1984.80
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发表时间：
1984-04
影响因子：
8.8
通讯作者：
Siurala, M
中科院分区：
文献类型：
--
作者：
Sipponen, P;Kekki, M;Siurala, M
本文对476例经胃镜检查和生物学证实的胃癌（GC）进行了胃炎和肠上皮化生（IM）的动态研究，其中肠型（IGC）263例，弥漫型（DGC）213例。在所有病例中，肿瘤周围区域的内窥镜活检标本均可用，238例病例中，肿瘤区域远处的胃窦和/或体部活检标本可用。使用由431名受试者组成的经内窥镜和生物光学检查的芬兰人群的代表性样本作为对照材料。在IGC患者中，受肿瘤影响的胃区域萎缩性胃炎的患病率较高，浅表性胃炎的患病率低于预期，胃炎和IM的年龄组评分均高于研究的所有年龄组中对照组胃炎评分的年龄依赖性线。这表明IGC患者的胃炎进展比一般人群更快。在胃的相对区域，即在无肿瘤区域，胃炎和IM的进展几乎与对照组相似。在DGC方面没有看到这种差异。它的结论是，IGC是动态密切相关的胃炎和IM，而在DGC没有这样的关系是显而易见的。
Age-related trends of gastritis and intestinal metaplasia (IM) were studied in 476 endoscopically examined and bioptically proved cases of gastric carcinoma (GC), 263 of which were of intestinal (IGC) and 213 of diffuse (DGC) types. Endoscopic biopsy specimens from the area around the tumour were available in all cases, and from the antrum and/or body distant from the tumour area in 238 cases. A representative sample of an endoscopically and bioptically examined Finnish population consisting of 431 subjects was used as control material. In patients with IGC the prevalence of atrophic gastritis in the gastric area affected by the tumour was higher and that of superficial gastritis lower than expected, and the age-group scores of gastritis and IM were situated above the age-dependent line of gastritis scores of controls in all age groups studied. This was seen to indicate a more rapid progression of gastritis in IGC patients than in the population at large. In the opposite area of the stomach, i.e. in the tumour-free area, the progression of gastritis and IM was virtually similar to that in controls. No such differences were seen with regard to DGC. It is concluded that IGC is dynamically closely linked to gastritis and IM, while in DGC no such relationship is demonstrable.