Factors affecting erectile function after radical retropubic prostatectomy: results from 1620 consecutive patients
Factors affecting erectile function after radical retropubic prostatectomy: results from 1620 consecutive patients
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DOI：
10.1111/j.1464-410x.2007.07409.x
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发表时间：
2008-04-01
影响因子：
4.5
通讯作者：
Soloway, Mark S.
中科院分区：
文献类型：
--
作者：
Ayyathurai, Rajinikanth;Manoharan, Murugesan;Soloway, Mark S.
OBJECTIVETo report the return of erectile function in 1620 consecutive men after radical retropubic prostatectomy (RRP), chosen by half of men diagnosed with clinically localized prostate cancer, and the goal of which is to completely excise the tumour while preserving continence and erectile function.PATIENTS AND METHODSFrom January 1992 to October 2006, one surgeon performed RRP with a nerve-sparing technique where feasible. Men with erectile dysfunction before surgery, salvage RRPs, those not having a nerve-sparing procedure, neoadjuvant or adjuvant therapy within 6 months of RRP and a follow-up of < 6 months were excluded from the analyses. Erectile function was evaluated by the surgeon when possible or by an annual questionnaire. Potency was defined as erectile function sufficient for intercourse with or without a phosphodiesterase-5 inhibitor.RESULTSOf 619 men who had a bilateral and of 178 who had a unilateral nerve-sparing RRP, 72% and 53%, respectively, were potent. When stratifying by age groups (= 70 years) potency rates were 86%, 76%, 58% and 37%, respectively. Potency was more common after bilateral than unilateral nerve-sparing RRP in all age groups (P < 0.001). Age, bilateral nerve-sparing (odds ratio 2.9) and surgeon experience were associated with potency in a multivariate analysis.CONCLUSIONSCareful patient selection and meticulous surgical technique are essential to achieve the right balance between cancer control and morbidity. The patient's age, nerve-sparing RRP and the surgeon's experience were the significant predictors of return of potency after RRP.
