Evaluation of radiation exposure in Ir-192 brachytherapy for treatment of keloids
Evaluation of radiation exposure in Ir-192 brachytherapy for treatment of keloids
复制标题
Ir-192 近距离放射治疗瘢痕疙瘩的辐射暴露评估
DOI：
10.1016/j.egypro.2017.09.424
复制
发表时间：
2017
期刊：
影响因子：
--
通讯作者：
N. Hayashizaki
中科院分区：
文献类型：
--
作者：
M. Ohta;N. Nakao;S. Kuribayashi;Tsuguhiro Miyashita;N. Shigematsu;N. Hayashizaki
日本医学院医院最近开发了一种治疗瘢痕疙瘩的高剂量率浅层近距离放射治疗(HDR-SBT)，自2008年以来一直在进行。在这种治疗中，Ir-192源通过软管放置在受影响的区域，具有为复杂形状提供高剂量浓度的优点。显然，必须减少受影响区域周围重要器官不必要的高能伽马射线辐射暴露。我们根据HDR-SBT的实际几何形状，利用PHITS蒙特卡罗程序开发了一个系统，该系统可以评估MIRD-5模型中的组织和器官在规定剂量均匀照射到平坦表面时的辐射照射。在PHITS模拟中，假设MIRD-5体模的胸部有一个受影响的区域，然后优化每个驻留位置的停留时间，使其在实际几何形状的受影响区域上以铅屏和团注的形式均匀照射6Gy.此外，还计算了MIRD-5体模中各组织器官在辐照过程中的辐射照射量。胸腺的生物等效剂量最高，为1145.60 mGy.心脏次之，为236.14 mGy.乳房为95.32mGy.
Nippon Medical School Hospital recently developed a high dose rate superficial brachytherapy (HDR-SBT) for keloids, which has been carried out since 2008. In this treatment, Ir-192 sources are placed on the affected area through flexible tubes, which has the advantage of providing high dose concentration to complicated shapes. Obviously, unnecessary radiation exposure to high-energy gamma rays must be reduced for vital organs around the affected area. We have developed a system which can evaluate the radiation exposure of tissues and organs in a MIRD-5 phantom using the PHITS Monte Carlo code when the prescribed dose was delivered uniformly to a flat surface based on the actual geometry in HDR-SBT. In the PHITS simulation, an affected area was assumed on the chest of the MIRD-5 phantom, then the dwell time at each dwell position was optimized to deliver 6 Gy uniformly over the affected area in the actual geometry with the lead shields and the bolus. In addition, the radiation exposures of each tissue and organ in the MIRD-5 phantom during the irradiation were calculated. The biologically equivalent dose of the thymus was the highest at 1145.60 mGy followed by the heart at 236.14 mGy and the breasts at 95.32 mGy.
影响因子：
1.2
作者：
Sato, Tatsuhiko;Niita, Koji;Sihver, Lembit
通讯作者：
Sihver, Lembit