Atopy in childhood. III. Relationship with pulmonary function and airway responsiveness
Atopy in childhood. III. Relationship with pulmonary function and airway responsiveness
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童年时有特应性。
DOI：
--
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发表时间：
1993
影响因子：
6.1
通讯作者：
M. Holdaway
中科院分区：
文献类型：
--
作者：
Malcolm R. Sears;Benjamin Burrows;G. Herbison;E. Flannery;M. Holdaway
儿童特应性与肺功能之间的关系，以及这些与气道高反应性之间的直接或间接关系尚不确定。我们在一个13岁的孩子样本中研究了这些关系。新西兰儿童出生队列的662名成员（341名男孩）完成了关于呼吸道症状的问卷调查、11种常见过敏原的皮肤点刺试验、肺量测定和简化乙酰甲胆碱激发试验，纵向随访至13岁。特应性的存在和程度与基线肺功能之间存在显著关系。低FEV 1/VC比值与气道反应性的可能性更大相关，不仅在诊断为哮喘的受试者中，而且在整个队列和426名否认哮喘或当前喘息的儿童亚组中也是如此。特应性儿童的基线FEV 1/VC和气道反应性之间的关系比非特应性儿童更强，对屋尘螨和/或猫皮屑敏感的儿童的关系最强。在存在特应性的情况下，肺功能水平的逐渐降低与气道反应性的发生率较高密切相关（P < 0.001）。在非特应性受试者中，只有肺功能受损最严重的受试者（FEV 1/VC <75%）显示出气道反应性的任何实质性患病率。特应性程度与FEV 1/VC比值之间的关系虽然在单变量分析中具有显著性，但在考虑气道反应性后变得完全不显著。在13岁的儿童中，特应性，特别是屋尘螨和猫皮屑，与肺功能（以FEV 1/VC比值表示）相关。气道反应性同样与基线肺功能受损相关。肺功能与特应性的明显关系主要是由于特应性与气道反应性之间的关系。特应性和肺功能受损是预测气道反应性的附加因素。
The relationship between atopy and pulmonary function in children, and how these relate directly or indirectly to airway hyperresponsivcness, is uncertain. We have examined these relationships in a sample of 13‐year‐old children. A questionnaire on respiratory symptoms, skin‐prick tests to 11 common allergens, spirometry and an abbreviated methacholine challenge test were completed by 662 members (341 boys) of a birth cohort of New Zealand children followed longitudinally to age 13. There was a significant relationship between the presence and degree of atopy, and baseline pulmonary function. Low FEV1/VC ratios were associated with a greater likelihood of airway responsiveness, not only in subjects with diagnosed asthma, but also in the full cohort and in the sub‐group of 426 children who denied asthma or current wheeze. The relationships between baseline FEV1/VC and airway responsiveness were stronger in atopic than in non‐atopic children, with the strongest relationships in children sensitive to house dust mite and/or cat dander. In the presence of atopy, progressively lower levels of lung function were strongly associated with a higher prevalence of airway responsiveness (P < 0.001). In non‐atopic subjects, only those with the most impaired lung function (FEV1/VC <75%) showed any substantive prevalence of airway responsiveness. The relationship between the degree of atopy and the FEV1/VC ratio, although significant in univariate analysis, became completely non‐significant after accounting for airway responsiveness. In 13‐year‐old children, atopy, especially to house dust mite and cat dander, was correlated with pulmonary function expressed as FEV1/VC ratio. Airway responsiveness likewise correlated with impaired baseline lung function. The apparent relationship of lung function to atopy occurred primarily as a result of the relationship between atopy and airway responsiveness. Atopy and impaired lung function were additive factors predicting airway responsiveness.
年龄和肺功能水平对非特异性气道反应性的影响。
DOI：
10.1164/ajrccm/143.5_pt_1.978
发表时间：
1991
期刊：
The American review of respiratory disease
影响因子：
--
作者：
Sparrow,D;O'Connor,GT;Rosner,B;Segal,MR;Weiss,ST
通讯作者：
Weiss,ST
影响因子：
158.5
作者：
SEARS, MR;BURROWS, B;HOLDAWAY, MD
通讯作者：
HOLDAWAY, MD