Blood rheology and proliferative retinopathy in sickle cell-haemoglobin C disease.
Blood rheology and proliferative retinopathy in sickle cell-haemoglobin C disease.
复制标题
镰状细胞血红蛋白 C 病中的血液流变学和增殖性视网膜病。
DOI：
10.1136/bjo.68.5.325
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发表时间：
1984
影响因子：
4.1
通讯作者：
G. Serjeant
中科院分区：
文献类型：
--
作者：
B. Serjeant;K. Mason;P. Condon;R. Hayes;M. Kenny;J. Stuart;G. Serjeant
研究人员对 31 对年龄性别匹配的镰状细胞血红蛋白 C 病患者（伴或不伴增生性镰状视网膜病 (PSR)）的血液学和流变学（血浆和血清粘度、全血粘度和红细胞滤过性）因素进行了研究。与匹配对照相比，PSR 患者的平均细胞血红蛋白水平显着较高，而 Hb F 水平平均较低，但两组之间的粘度和红细胞滤过指数没有差异。因此，尽管不能排除 PSR 发生时短暂的流变学异常，但在研究时没有证据表明患有和不患有 PSR 的患者之间存在流变学差异。为了检测此类变化，有必要对 PSR 开发之前、期间和之后的流变学进行前瞻性纵向研究。
Haematological and rheological (plasma and serum viscosity, whole blood viscosity, and erythrocyte filterability) factors were studied in 31 age-sex matched pairs of patients with sickle cell haemoglobin C disease with and without proliferative sickle retinopathy (PSR). Patients with PSR had significantly higher mean cell haemoglobin and lower Hb F levels on average than the matched controls, but the viscosity and erythrocyte filtration indices did not differ between the 2 groups. There was, therefore, no evidence of rheological differences between patients with and without PSR at the time of the study, although transient rheological abnormalities at the time of development of PSR could not be excluded. Prospective longitudinal studies of rheology before, during, and after the development of PSR would be necessary to detect such changes.