Symptoms and immunoglobulin development in hospital staff exposed to a SARS-CoV-2 outbreak
Symptoms and immunoglobulin development in hospital staff exposed to a SARS-CoV-2 outbreak
复制标题
DOI：
10.1111/pai.13278
复制
发表时间：
2020-06-18
影响因子：
4.4
通讯作者：
Kabesch, Michael
中科院分区：
文献类型：
--
作者：
Brandstetter, Susanne;Roth, Samra;Kabesch, Michael
背景：在全球范围内，SARS-CoV-2感染的数量正在增加。血清免疫球蛋白检测可能有助于更好地了解新冠肺炎病例和暴露但没有症状的个人对SARS-CoV-2的免疫机制的发展。这项研究的目的是调查新冠肺炎暴发后的大样本医护人员对SARS-CoV-2的暴露、症状和抗体反应。方法对德国一家大型妇儿医院发生的新冠肺炎疫情进行大规模RT-PCRSARS-CoV-2检测，以研究SARS-CoV-2的症状、感染链以及SARS-CoV-2特异性抗体应答。研究参与者分别被归类为新冠肺炎病例和临床环境中与SARS-CoV-2有密切、中度或无暴露关系的人。结果201例研究对象中，新冠肺炎患者31例。虽然大多数研究参与者经历了许多表明感染SARS-CoV-2的症状，但嗅觉障碍和咳嗽在新冠肺炎患者中明显更常见。约80%的新冠肺炎病例在症状出现约3周后产生某种特异性抗体应答(IgA和Ig G)。与病例接触史无关，非新冠肺炎人群中的免疫球蛋白Ig G(1.8%)和免疫球蛋白A值(7.6%)也升高。结论我们发现相当数量的患者在症状出现三周后没有产生相应的抗体反应。我们的数据还表明，在医院环境中接触新冠肺炎阳性的同事并不会导致相当大比例的无症状接触者出现可测量的免疫反应。
Background Worldwide, the number of SARS-CoV-2 infections is increasing. Serological immunoglobulin tests may help to better understand the development of immune mechanisms against SARS-CoV-2 in COVID-19 cases and exposed but asymptomatic individuals. The aim of this study was to investigate exposure to SARS-CoV-2, symptoms, and antibody responses in a large sample of healthcare workers following a COVID-19 outbreak. Methods A COVID-19 outbreak among staff members of a major German children's and women's hospital was followed by massive RT-PCR SARS-CoV-2 tests and provided the opportunity to study symptoms, chains of infection, and SARS-CoV-2-specific antibody responses (IgG and IgA) by ELISA. Study participants were classified as COVID-19 cases, and persons with close, moderate, or no exposure to SARS-CoV-2 in the clinical setting, respectively. Results Out of 201 study participants, 31 were COVID-19 cases. While most study participants experienced many symptoms indicative for SARS-CoV-2 infection, anosmia and coughing were remarkably more frequent in COVID-19 cases. Approximately 80% of COVID-19 cases developed some specific antibody response (IgA and IgG) approximately 3 weeks after onset of symptoms. Subjects in the non-COVID-19 groups had also elevated IgG (1.8%) and IgA values (7.6%) irrespective of contact history with cases. Conclusion We found that a significant number of diseased did not develop relevant antibody responses three weeks after symptom onset. Our data also suggest that exposure to COVID-19 positive co-workers in a hospital setting is not leading to the development of measurable immune responses in a significant proportion of asymptomatic contact persons.