Second-Generation Total Synthesis of Spirastrellolide F Methyl Ester: The Alkyne Route
Second-Generation Total Synthesis of Spirastrellolide F Methyl Ester: The Alkyne Route
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DOI：
10.1002/anie.201103270
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发表时间：
2011-01-01
影响因子：
16.6
通讯作者：
Fuerstner, Alois
中科院分区：
文献类型：
--
作者：
Benson, Stefan;Collin, Marie-Pierre;Fuerstner, Alois
古怪的：螺环内酯F甲酯中嵌入的螺缩酮是一个大胆的闭环位点，但它允许展示催化炔断裂和活化的能力。还开发了引入不稳定侧链的改进策略。
Outlandish: The spiroketal embedded in spirastrellolide F methyl ester is a daring site for ring closure, yet it has allowed the power of catalytic alkyne scission and activation to be showcased. An improved strategy for the introduction of the labile side chain was also developed.