Mucormycosis of the nose and paranasal sinuses
Mucormycosis of the nose and paranasal sinuses
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DOI：
10.1016/s0030-6665(00)80010-9
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发表时间：
2000-04-01
影响因子：
1.7
通讯作者：
Ferguson, BJ
中科院分区：
文献类型：
--
作者：
Ferguson, BJ
鼻脑毛霉菌病是一种始于鼻旁窦的侵袭性真菌感染，经常进展至眼眶和大脑受累。如果及早发现，受累仅限于鼻腔和鼻旁窦。糖尿病控制不佳的风险最大，然而，任何免疫功能低下的个体都可能被感染。主要治疗方法是逆转免疫抑制、全身性两性霉素 B 和手术清创。生存率已显着提高，但如果感染没有在病程早期得到识别和治疗，或者免疫功能低下的根源不可逆转，死亡仍然会发生。几个案例说明了这种不寻常但可能致命的真菌感染的临床过程。详细回顾了鼻窦毛霉菌病的分类、临床表现、诊断和治疗。
Rhinocerebral mucormycosis is an invasive fungal infection initiated in the paranasal sinuses that frequently progresses to orbital and brain involvement. If recognized early, involvement is limited to the nasal cavity and paranasal sinuses. Diabetics in poor control are at greatest risk, however, any immunocompromised individual may be infected. The mainstays of therapy are reversal of immunosuppression, systemic amphortericin B, and surgical debridement. Survival has improved dramatically, yet deaths still occur if the infection is not recognized and not treated early in its course or if the source of immunocompromise is not reversible. Several case examples illustrate the clinical course of this unusual, but potentially fatal, fungal infection. Taxonomy, clinical presentation, diagnosis, and management of mucormycosis of the paranasal sinuses are reviewed in detail.