New Topics in Vasopressin Receptors and Approach to Novel Drugs: Role of the Vasopressin Receptor in Psychological and Cognitive Functions
New Topics in Vasopressin Receptors and Approach to Novel Drugs: Role of the Vasopressin Receptor in Psychological and Cognitive Functions
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DOI：
10.1254/jphs.08r14fm
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发表时间：
2009-01-01
影响因子：
3.5
通讯作者：
Fujiwara, Michihiro
中科院分区：
文献类型：
--
作者：
Egashira, Nobuaki;Mishima, Kenichi;Fujiwara, Michihiro
精氨酸加压素（AVP）是一种神经垂体肽，最为人所知的抗利尿激素。AVP受体分为三种亚型：V1a、V1b和V2受体。V1a受体（V1aR）和V1b受体（V1bR）广泛分布于中枢神经系统，包括隔区、皮质、海马和下丘脑。临床研究表明AVP参与精神疾病。在本研究中，我们研究了V1aR或V1bR敲除（KO）小鼠与野生型（WT）小鼠在行为测试中的表现。与WT小鼠相比，V1aR和V1bR KO小鼠表现出社会行为和前脉冲抑制的缺陷。此外，V1aR KO小鼠表现出减少的焦虑样行为和空间学习障碍。这些结果表明V1aR和V1bR在心理和认知功能中起重要作用。
Arginine vasopressin (AVP) is a neurohypophyseal peptide best known as an antidiuretic hormone. AVP receptors have been classified into three subtypes: V1a, V1b, and V2 receptors. V1a receptor (V1aR) and V1b receptor (V1bR) are widely distributed in the central nervous system, including the septum, cortex, hippocampus, and hypothalamus. Clinical studies have demonstrated an involvement of AVP in psychiatric disorders. In the present study, we examined the performance of V1aR or V1bR knockout (KO) mice compared to wild-type (WT) mice in behavioral tests. V1aR and V1bR KO mice exhibited deficits of social behavior and prepulse inhibition in comparison to WT mice. Moreover, V1aR KO mice exhibited reduced anxiety-like behavior and impairment of spatial learning. These results suggest that V1aR and V1bR play an important role in psychological and cognitive functions.