A Novel Galactosyltransferase Inhibitor with Diamino Sugar as a Pyrophosphate Mimic
A Novel Galactosyltransferase Inhibitor with Diamino Sugar as a Pyrophosphate Mimic
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DOI：
10.1002/ejoc.200801285
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发表时间：
2009-04-01
影响因子：
2.8
通讯作者：
Yuasa, Hideya
中科院分区：
文献类型：
--
作者：
Mitsuhashi, Nobuyuki;Yuasa, Hideya
已经合成了2，4-二氨基糖和尿苷的缀合物作为半乳糖基转移酶抑制剂。用核磁共振谱研究了铰链状二氨基糖对金属离子的螯合能力与抑制活性的关系。其中一种缀合物表现出中等程度的抑制作用，可能是通过铰链样二氨基糖与Mn-II的螯合作用，这种抑制作用介于UDP和UMP之间。((C)Wiley-VCH Verlag GmbH & Co. KGaA，69451魏因海姆，德国，2009）
Conjugates of 2,4-diamino sugars and uridine have been synthesized as galactosyltransferase inhibitors. The relationship between inhibitory activity and the chelation abilility of the hinge-like diamino sugar towards a metal ion was studied by NMR spectroscopy. One of the conjugates exhibited a moderate inhibition that ranks between those of UDP and UMP probably through the chelation of the hinge-like diamino sugar to Mn-II. ((C) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)