Capturing circulating endothelial progenitor cells: a new concept tested in the HEALING studies.
Capturing circulating endothelial progenitor cells: a new concept tested in the HEALING studies.
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发表时间：
2006-02
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通讯作者：
S. Silber
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作者：
S. Silber
心脏病学实践和医院，慕尼黑，德国S已成为经皮冠状动脉介入治疗（PCI）的标准程序。1支架的致命弱点-支架相关再狭窄-已几乎（但不完全）被许多药物洗脱支架（DES）解决。今天，DES在美国和瑞士的使用率超过80%，在其他国家的渗透率较低。然而，DES支架植入术的新致命弱点似乎是晚期支架血栓形成：2-4由于延迟愈合，DES需要更长时间添加氯吡格雷至乙酰水杨酸药物。如果过早停用氯吡格雷，支架内血栓形成及其固有的高死亡率是一个可能的威胁。因此，开发了一种新概念，通过将血流中的循环内皮祖细胞捕获到专门设计的支架上来提高支架愈合速度。5 -7
Cardiology Practice and Hospital, Munich, Germany S has become a standard procedure in percutaneous coronary interventions (PCI).1 The Achilles’ heel of stenting—the stent-related restenosis—has been almost (but not totally) resolved by many drug-eluting stents (DES). Today, DES are used in over 80% in the USA and in Switzerland with lower penetration rates in other countries. The new Achilles’ heel of stenting with DES, however, seems to be late stent thrombosis:2-4 due to delayed healing, DES require longer addition of clopidogrel to acetylsalicylic acid drug. If clopidogrel is discontinued too early, stent thrombosis with its inherent high mortality, is a possible threat. Therefore, a new concept was developed, enhancing the speed of stent healing by capturing circulating endothelial progenitor cells from the blood stream onto a specially designed stent.5-7