Hydroxyapatite coating for titanium fibre mesh scaffold enhances osteoblast activity and bone tissue formation
Hydroxyapatite coating for titanium fibre mesh scaffold enhances osteoblast activity and bone tissue formation
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DOI：
10.1016/j.ijom.2011.12.035
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发表时间：
2012-10-01
影响因子：
2.4
通讯作者：
Tohnai, Iwai
中科院分区：
文献类型：
--
作者：
Hirota, Makoto;Hayakawa, Tohru;Tohnai, Iwai
本研究探讨钛纤维网作为组织工程材料的骨再生性能。采用分子前驱体法在钛纤维网上制备了一层薄的羟基磷灰石（HA）涂层，同时保持了钛纤维网复杂的内部结构。HA涂层钛纤维补片在体外人成骨细胞培养中显示磷灰石晶体形成。将有或没有薄HA涂层的钛纤维网状圆盘植入大鼠颅骨缺损中，并在2周和4周时处死动物。体内经验表明，植入后2周，HA涂层钛纤维补片中的新骨形成量显著高于非涂层钛纤维补片。这些结果表明，薄HA涂层增强了钛纤维网状支架中的成骨细胞活性和骨再生。薄HA涂层提高了钛纤维网作为骨再生支架的能力。
This study investigated the bone regeneration properties of titanium fibre mesh as a tissue engineering material. A thin hydroxyapatite (HA) coating on the titanium fibre web was created using the developed molecular precursor method without losing the complex interior structure. HA-coated titanium fibre mesh showed apatite crystal formation in vitro in a human osteoblast culture. Titanium fibre mesh discs with or without a thin HA coating were implanted into rat cranial bone defects, and the animals were killed at 2 and 4 weeks. The in vivo experience revealed that the amount of newly formed bone was significantly higher in the HA-coated titanium fibre mesh than in the non-coated titanium fibre mesh 2 weeks after implantation. These results suggest that thin HA coating enhances osteoblast activity and bone regeneration in the titanium fibre mesh scaffold. Thin HA-coating improved the ability of titanium fibre mesh to act as a bone regeneration scaffold.