Juvenile mice show greater flexibility in multiple choice reversal learning than adults
Juvenile mice show greater flexibility in multiple choice reversal learning than adults
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DOI：
10.1016/j.dcn.2011.05.008
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发表时间：
2011-10-01
影响因子：
4.7
通讯作者：
Wilbrecht, Linda
中科院分区：
文献类型：
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作者：
Johnson, Carolyn;Wilbrecht, Linda
我们假设，决策策略在幼年动物，而不是不成熟，优化导航的不确定性和不稳定性可能会遇到的环境中的动物的过渡到独立的时间。我们测试了少年和年轻的成年小鼠的歧视和逆转的4选择和2选择气味为基础的觅食任务。幼年小鼠（P26-27）比成年小鼠（P60-70）更快地学习4选择辨别和逆转，犯更少的坚持和分心错误。幼年小鼠具有更短的选择时间和更集中的搜索策略。在这两个年龄段，任务的性能显着受损的背内侧额叶皮层的病变。我们的数据表明，额叶皮层可以支持高度灵活的行为在幼年小鼠在断奶和第一次独立的时间一致。一个月后，行为灵活性的意外发育下降表明，基于额叶皮层的执行功能可能不一定会随着年龄的增长而变得更加灵活，而是可能会在发育上进行调整，以优化每个生命阶段的探索和剥削行为。(C)2011爱思唯尔有限公司保留所有权利。
We hypothesized that decision-making strategies in juvenile animals, rather than being immature, are optimized to navigate the uncertainty and instability likely to be encountered in the environment at the time of the animal's transition to independence. We tested juvenile and young adult mice on discrimination and reversal of a 4-choice and 2-choice odor-based foraging task. Juvenile mice (P26-27) learned a 4-choice discrimination and reversal faster than adults (P60-70), making fewer perseverative and distraction errors. juvenile mice had shorter choice latencies and more focused search strategies. In both ages, performance of the task was significantly impaired by a lesion of the dorsomedial frontal cortex. Our data show that the frontal cortex can support highly flexible behavior in juvenile mice at a time coincident with weaning and first independence. The unexpected developmental decline in flexibility of behavior one month later suggests that frontal cortex based executive function may not inevitably become more flexible with age, but rather may be developmentally tuned to optimize exploratory and exploitative behavior for each life stage. (C) 2011 Elsevier Ltd. All rights reserved.