CALCIUM-REGULATING HORMONES IN ESSENTIAL-HYPERTENSION - RELATION TO PLASMA-RENIN ACTIVITY AND SODIUM-METABOLISM
CALCIUM-REGULATING HORMONES IN ESSENTIAL-HYPERTENSION - RELATION TO PLASMA-RENIN ACTIVITY AND SODIUM-METABOLISM
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DOI：
10.7326/0003-4819-105-5-649
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发表时间：
1986-11-01
影响因子：
39.2
通讯作者：
LARAGH, JH
中科院分区：
文献类型：
--
作者：
RESNICK, LM;MULLER, FB;LARAGH, JH
研究人员分析了 10 名血压正常者和 51 名原发性高血压患者的钙调节激素、降钙素、骨化三醇和甲状旁腺激素的循环水平与血浆肾素活性的关系。与正常血压对照和其他高血压患者相比，肾素活性低的高血压患者的骨化三醇（p < 0.008）和甲状旁腺激素（p < 0.01）水平升高，而肾素活性高的患者降钙素水平较高（p < 0.008）。所有患者的骨化醇水平和血浆肾素活性之间均观察到连续关系（r = -0.65，p < 0.001），肾素活性低的高血压患者的甲状旁腺激素水平和尿钠排泄之间也存在连续关系（r = 0.63，p < 0.01）。总之，这些结果支持原发性高血压中钙代谢和肾素钠因子之间的联系。钙调节激素和肾素醛固酮系统可以通过改变细胞对单价和二价离子的处理，在细胞水平上协调介导不同膳食钙和钠摄入量对血压的影响。
Circulating levels of the calcium-regulating hormones, calcitonin, calcitriol, and parathyroid hormone, were analyzed in relation to plasma renin activity in 10 persons with normal blood pressure and in 51 persons with essential hypertension. Calcitriol (p < 0.008) and parathyroid hormone (p < 0.01) levels were elevated in hypertensives with low renin activity, whereas calcitonin levels were higher in patients with high renin activity (p < 0.008), compared with normotensive controls and other hypertensive patients. Continuous relationships were observed between calcitrol levels and plasma renin activity in all patients (r = -0.65, p < 0.001) and between parathyroid hormone levels and urinary sodium excretion in hypertensive patients with low renin activity (r = 0.63, p < 0.01). Together, these results support a linkage between calcium metabolism and renin-sodium factors in essential hypertension. Calcium-regulating hormones and the renin-aldosterone system may coordinately mediate the blood pressure effects of differing dietary calcium and sodium intakes at the cellular level by altering cellular handling of monovalent and divalent ions.