Early postnatal allopurinol does not improve short term outcome after severe birth asphyxia
Early postnatal allopurinol does not improve short term outcome after severe birth asphyxia
复制标题
DOI：
10.1136/adc.2005.086652
复制
发表时间：
2006-05-01
影响因子：
4.4
通讯作者：
van Bel, F
中科院分区：
文献类型：
--
作者：
Benders, MJNL;Bos, AF;van Bel, F
目的：探讨出生后别嘌醇能否减轻重度窒息新生儿脑组织自由基致再灌注/复氧损伤。方法：采用随机、双盲、安慰剂对照研究，对32例重度窒息新生儿在出生后4小时内给予别嘌醇或安慰剂治疗。结果：应用别嘌醇治疗的新生儿死亡率和发病率无明显变化。结论：出生后给予别嘌醇治疗太晚，不能减少早期再灌流引起的自由基激增。在分娩过程中，通过母亲给缺氧的胎儿注射别嘌醇可能更有效地减少自由基致窒息后的脑损伤。
Objective: To investigate whether postnatal allopurinol would reduce free radical induced reperfusion/reoxygenation injury of the brain in severely asphyxiated neonates.Method: In an interim analysis of a randomised, double blind, placebo controlled study, 32 severely asphyxiated infants were given allopurinol or a vehicle within four hours of birth.Results: The analysis showed an unaltered (high) mortality and morbidity in the infants treated with allopurinol.Conclusion: Allopurinol treatment started postnatally was too late to reduce the early reperfusion induced free radical surge. Allopurinol administration to the fetus with (imminent) hypoxia via the mother during labour may be more effective in reducing free radical induced post-asphyxial brain damage.