Resistant Starch‐Supplemented Udon Noodles Prevent Impaired Glucose Tolerance and Induce Intestinal Immunoglobulin‐A Secretion in Mice
Resistant Starch‐Supplemented Udon Noodles Prevent Impaired Glucose Tolerance and Induce Intestinal Immunoglobulin‐A Secretion in Mice
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添加抗性淀粉的乌冬面可预防小鼠葡萄糖耐量受损并诱导肠道免疫球蛋白 A 分泌
DOI：
10.1002/star.201900042
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发表时间：
2019
期刊：
影响因子：
--
通讯作者：
Kida N
中科院分区：
文献类型：
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作者：
Matsumoto K;Shimada H;Morishima H;Akahori R;Kida N
抗性淀粉（RS）最近因其对葡萄糖/脂质代谢和肠道状况的潜在益处而受到相当大的关注。制备添加 RS 的乌冬面 (RS-Udon)，并在 C57BL/6J 小鼠中将其功能特性与不含 RS 的乌冬面 (C-Udon) 进行比较。两种乌冬面样品均在冻干后使用。单次服用 RS-乌冬面（250mg/kg−1 体重，口服）在 30 分钟内增加的血糖水平往往低于 C-乌冬面引起的血糖水平。在一项为期 13 周的治疗研究中，给小鼠喂食正常饮食或高脂肪饮食（HFD；45kcal% 脂肪），并辅以 30% C-Udon（HFD-C 组）或 RS-Udon（HFD-RS 组）。 RS-乌冬面摄入可显着预防 HFD 引起的糖耐量受损。与 HFD-C 组相比，HFD 组粪便中免疫球蛋白-A 水平显着升高，粪便粘蛋白含量也出现这种趋势。 HFD-RS 组的盲肠丙酸含量比 HFD-C 组高 1.8 倍，这可能是丙酸对葡萄糖代谢的有益作用所致。在 HFD-RS 组中没有观察到对脂质代谢的有益影响。这些结果表明，摄入 RS-乌冬面可能对葡萄糖代谢和肠道免疫状况产生有益影响。
Resistant starch (RS) has received considerable attention recently because of its potential benefits upon glucose/lipid metabolism and intestinal conditions. RS‐supplemented Udon noodles (RS‐Udon) are prepared and their functional properties are compared with those of Udon noodles without RS (C‐Udon) in C57BL/6J mice. Both Udon samples are used after lyophilization. Single administration (250 mg kg−1body weight, p.o.) of RS‐Udon tends to increase blood glucose levels less than that elicited by C‐Udon at 30 min. In a 13‐week‐treatment study, mice are fed a normal diet or a high‐fat diet (HFD; 45 kcal% fat) supplemented with 30% C‐Udon (HFD‐C group) or RS‐Udon (HFD‐RS group). RS‐Udon intake prevents the impaired glucose tolerance caused by HFD significantly. Fecal levels of immunoglobulin‐A are increased significantly in the HFD group compared with that in the HFD‐C group, a tendency that is also observed in fecal mucin content. The HFD‐RS group shows cecal propionate content 1.8‐fold higher than that in the HFD‐C group, which may be secondary to the beneficial effects of propionate upon glucose metabolism. Beneficial effects upon lipid metabolism are not observed in the HFD‐RS group. These results suggest that RS‐Udon ingestion may have beneficial effects on glucose metabolism and intestinal immune conditions.