Reduced breast cancer risk after remarriage: evidence of genetic-immune protection.
Reduced breast cancer risk after remarriage: evidence of genetic-immune protection.
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再婚后乳腺癌风险降低：遗传免疫保护的证据。
DOI：
10.1097/00001648-199505000-00011
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发表时间：
1995
期刊：
影响因子：
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通讯作者：
Thompson,WD
中科院分区：
文献类型：
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作者：
Janerich,DT;Thompson,WD
已发现多种生殖因素与乳腺癌有关。基于对这些观察结果的免疫学而非严格的激素解释，我们假设，除了观察到的与怀孕本身相关的关联之外，多重婚姻还可以保护女性免受乳腺癌的侵害。我们从犹他州癌症登记处的链接记录和家谱记录中获取了病例和对照。总共包括 2,414 名新诊断乳腺癌的女性和 9,138 名单独匹配的对照者。第一次婚姻后每段婚姻的未调整优势比为 0.81 [95% 置信区间 (CI)= 0.68–0.97]。调整主要生殖因素后，多婚仍可降低乳腺癌风险（比值比= 0.86；95% CI= 0.72-1.03）。这些发现与乳腺癌病因学中免疫机制的运作一致，并表明导致这种效应的基因/抗原在男性中相当常见。似乎有必要对胎儿抗原假说进行进一步的实证评估。
Several reproductive factors have been found to be associated with breast cancer. Based on an immunologic rather than strictly hormonal interpretation of these observations, we hypothesized that, beyond the observed associations relating to pregnancy per se, multiple marriages would be found to protect women against breast cancer. We obtained cases and controls from linked records from the Utah Cancer Registry and genealogic records. A total of 2,414 women with newly diagnosed breast cancer and 9,138 individually matched controls were included. The unadjusted odds ratio for each marriage after the first was 0.81 [95% confidence interval (CI)= 0.68–0.97]. After adjustment for major reproductive factors, multiple marriages were still found to reduce the risk of breast cancer (odds ratio= 0.86; 95% CI= 0.72–1.03). The findings are consistent with the operation of an immunologic mechanism in the etiology of breast cancer and suggest that the gene/antigen responsible for this effect is quite common in males. Further empirical evaluation of the fetal antigen hypothesis seems warranted.