Pulmonary vascular resistance of children treated with nitrogen during early infancy.
Pulmonary vascular resistance of children treated with nitrogen during early infancy.
复制标题
婴儿早期接受氮治疗的儿童的肺血管阻力。
DOI：
10.1016/s0003-4975(98)00234-3
复制
发表时间：
1998
期刊：
影响因子：
--
通讯作者：
R. Shaddy
中科院分区：
文献类型：
--
作者：
R. Day;Alan J. Barton;T. Pysher;R. Shaddy
BackgroundWe have empirically used supplemental nitrogen in newborns with a functional single ventricle and ductal-dependent systemic perfusion to prevent pulmonary vasodilation and deliver a greater proportion of flow to the systemic circulation. Thus, we reviewed patient outcome to determine whether adverse pulmonary vascular effects may be associated with this therapy.MethodsFrom December 1991 to December 1995, the fraction of inspired oxygen was adjusted, with supplemental nitrogen if necessary, to maintain an oxygen saturation near 75% in 20 newborns awaiting heart transplantation. Medical records were reviewed to evaluate (1) the duration of nitrogen therapy, (2) pulmonary vascular histology, (3) postoperative pulmonary hemodynamics, and (4) survival.ResultsThirteen patients underwent heart transplantation, 4 patients died without surgical intervention, and 3 patients underwent late aortic reconstruction. Supplemental nitrogen was used without exceeding a fraction of inspired oxygen of 0.21 for 38 ± 6 days. One patient had evidence of changes of potentially irreversible pulmonary vascular disease. Pulmonary vascular resistance was not increased long-term in surviving patients.ConclusionsSupplemental nitrogen can be used to maintain a systemic oxygen saturation near 75% for an extended period in newborns with ductal-dependent systemic perfusion with no long-term adverse effect on pulmonary vascular resistance.
支气管动脉PO2对肺血管阻力的影响。
DOI：
10.1152/jappl.1991.70.1.405
发表时间：
1991
期刊：
Journal of applied physiology (Bethesda, Md. : 1985)
影响因子：
--
作者：
Marshall,BE;Marshall,C;Magno,M;Lilagan,P;Pietra,GG
通讯作者：
Pietra,GG
单心室生理学胎儿模型：产后早期氧气、一氧化氮、二氧化碳和缺氧的血流动力学影响。
DOI：
10.1016/s0022-5223(96)70272-6
发表时间：
1996
期刊：
The Journal of thoracic and cardiovascular surgery
影响因子：
--
作者：
Reddy,VM;Liddicoat,JR;Fineman,JR;McElhinney,DB;Klein,JR;Hanley,FL
通讯作者：
Hanley,FL