Metamemory without the memory: are people aware of midazolam-induced amnesia?
Metamemory without the memory: are people aware of midazolam-induced amnesia?
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DOI：
10.1007/s00213-004-1958-8
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发表时间：
2005-01-01
影响因子：
3.4
通讯作者：
Berrigan, M
中科院分区：
文献类型：
--
作者：
Merritt, P;Hirshman, E;Berrigan, M
基本原理：咪达唑仑是一种苯二氮卓类药物，可产生密集的顺行性遗忘，同时允许相对较好地保存短期记忆、语义检索和其他高级认知功能。鉴于这些保留的能力，我们感兴趣的是，是否参与者给予咪达唑仑将意识到这种顺行性遗忘。方法：在本实验中，参与者在一个测试阶段给予咪达唑仑，在另一个测试阶段给予生理盐水安慰剂。参与者提供的学习判断（JOLs）后，立即研究线索-目标对。在实验的测试阶段，收集了置信水平和认知感（FOK）判断。结果如下：虽然提示回忆性能在咪达唑仑条件下受到严重损害，但平均JOL不受影响，表明参与者在研究阶段对他们的损害几乎没有了解。参与者在咪达唑仑条件下的置信水平和FOK判断相对准确。结论：当在咪达唑仑的影响下学习物品时，参与者没有意识到他们的记忆会受到损害。遗忘症的临床实践和药理学研究的影响进行了讨论。
Rationale: Midazolam is a benzodiazepine which produces a dense anterograde amnesia, while permitting relatively well-preserved short-term memory, semantic retrieval, and other higher cognitive functions. Given these preserved abilities, we were interested in whether or not participants given midazolam would be aware of this anterograde amnesia. Method: In the present experiment, participants were given midazolam in one testing session and a saline placebo in another. Participants provided judgments-of-learning (JOLs) immediately following study of cue-target pairs. During the test phase of the experiment, confidence levels and feeling-of-knowing (FOK) judgments were collected. Results: Although cued recall performance was substantially impaired in the midazolam condition, mean JOLs were unaffected, indicating participants had little insight into their impairment during the study phase. Participants were relatively accurate in confidence levels and FOK judgments in the midazolam condition. Conclusion: When studying items under the influence of midazolam, participants are unaware that their memory will be impaired. Implications for clinical practice and pharmacological studies of amnesia are discussed.