Epidemiology and adverse cardiovascular risk profile of diagnosed polycystic ovary syndrome
Epidemiology and adverse cardiovascular risk profile of diagnosed polycystic ovary syndrome
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DOI：
10.1210/jc.2005-2430
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发表时间：
2006-04-01
影响因子：
5.8
通讯作者：
Go, AS
中科院分区：
文献类型：
--
作者：
Lo, JC;Feigenbaum, SL;Go, AS
内容：多囊卵巢综合征（PCOS）与月经和生殖异常、胰岛素抵抗和肥胖有关。目的：本研究的目的是确定确诊的PCOS的患病率及其与心血管危险因素的关系。设置：本研究设置在北方加州的一个综合卫生保健提供系统。患者：使用健康计划数据库，通过一个或多个PCOS门诊诊断，共确定了11，035名PCOS妇女。结果测量：测量PCOS患病率和心血管危险因素[高血压、血脂异常、糖尿病和体重指数（BMI）]。结果：在2002 - 2004年期间，25 - 34岁女性成员中诊断为PCOS的患病率为2.6%（95%置信区间为1.6 - 1.7%）。诊断为多囊卵巢综合征的女性比非多囊卵巢综合征的女性更容易肥胖[BMI >= 30 mg/m2;比值比（OR）4.21，3.96 - 4.47]。此外，PCOS与糖尿病（OR 2.45，置信区间2.16 - 2.79），高血压（OR 1.41，1.31 - 1.51）和已知的血脂异常（OR 1.53，1.39 - 1.68）相关，即使在调整BMI和已知混杂因素后。在PCOS患者中，与白人相比，黑人和西班牙裔更容易肥胖，亚洲人更不容易肥胖;亚洲人和西班牙裔更容易患糖尿病;黑人更容易患高血压，西班牙裔更不容易患高血压。在一个庞大的，以社区为基础的人口接受卫生保健，诊断的PCOS是高度流行的，并且与心血管危险因素的高频率相关，这些危险因素因种族/民族而异。我们的患病率估计可能低估了PCOS的真实患病率。还需要进一步的研究来探索种族/民族差异以及PCOS对未来心血管风险的影响程度。
Context: Polycystic ovary syndrome ( PCOS) is associated with menstrual and reproductive abnormalities, insulin resistance, and obesity.Objective: The objective of this study was to determine the prevalence of diagnosed PCOS and its association with cardiovascular risk factors.Setting: The study is set in an integrated health care delivery system in northern California.Patients: A total of 11,035 women with PCOS were identified by one or more outpatient diagnoses of PCOS using health plan databases. An age-matched sample of women without PCOS was also selected.Outcome Measures: Prevalence of PCOS and targeted cardiovascular risk factors [ hypertension, dyslipidemia, diabetes mellitus, and body mass index (BMI)] were measured.Results: During 2002 - 2004, the prevalence of diagnosed PCOS among female members aged 25 - 34 yr was 2.6% (95% confidence interval 1.6 - 1.7%). Women with diagnosed PCOS were more likely than those without PCOS to be obese [BMI >= 30 mg/m(2); odds ratio ( OR) 4.21, 3.96 - 4.47]. Furthermore, PCOS was associated with diabetes ( OR 2.45, confidence interval 2.16 - 2.79), hypertension ( OR 1.41, 1.31 - 1.51) and known dyslipidemia ( OR 1.53, 1.39 - 1.68), even after adjusting for BMI and known confounders. Among women with PCOS, compared with whites, Blacks and Hispanics were more likely and Asians less likely to be obese; Asians and Hispanics were more likely to have diabetes; and Blacks were more likely and Hispanics less likely to have hypertension.Conclusions: Within a large, community-based population receiving health care, diagnosed PCOS was highly prevalent and associated with a much higher frequency of cardiovascular risk factors that varied by race/ethnicity. Our prevalence estimates likely underestimate the true prevalence of PCOS. Further studies are needed to explore racial/ethnic differences and the extent to which PCOS contributes to future cardiovascular risk.