TGF-beta and CD4+ CD25+ regulatory T cells
TGF-beta and CD4+ CD25+ regulatory T cells
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DOI：
10.2741/1859
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发表时间：
2006-01-01
影响因子：
3.1
通讯作者：
Schramm, C
中科院分区：
文献类型：
--
作者：
Huber, S;Schramm, C
tgf - β和CD4(+)CD25（+）调节性T细胞（Treg）都在控制免疫应答和维持免疫稳态中发挥重要作用。Treg诱导的抑制机制以及调控Treg功能和数量的因子，目前才刚刚开始被阐明。tgf - β似乎作为一种效应细胞因子参与Treg在体内和体外的免疫抑制功能，尽管其来源和作用机制仍有待明确。此外，外周Treg中的tgf - β信号似乎对外周Treg数量的调节及其体内免疫抑制功能至关重要。本文将重点讨论tgf - β在CD4(+) CD25(+) Treg的生成和扩增中的作用，以及它们在体外和体内的免疫抑制功能。
TGF-beta and CD4(+)CD25(+) regulatory T cells ( Treg) both play an important role in the control of immune responses and the maintenance of immune homeostasis. The mechanism of suppression induced by Treg and the factors which regulate Treg function and number, have only begun to be elucidated. TGF-beta seems to act as an effector cytokine involved in the immunosuppressive function of Treg in vitro and in vivo, although its origin and mechanism of action remains to be defined. In addition, TGF-beta signaling in peripheral Treg seems to be essential for the regulation of peripheral Treg numbers and for their immunosuppressive function in vivo. This review will focus on the role of TGF-beta for the generation and expansion of CD4(+) CD25(+) Treg, as well as for their immunosuppressive function in vitro and in vivo.