Location of the trans-activating region on the genome of human T-cell lymphotropic virus type III.
Location of the trans-activating region on the genome of human T-cell lymphotropic virus type III.
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人类 T 细胞嗜淋巴细胞病毒 III 型基因组上反式激活区的位置。
DOI：
10.1126/science.2990041
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发表时间：
1985
期刊：
影响因子：
--
通讯作者：
Haseltine,W
中科院分区：
文献类型：
--
作者：
Sodroski,J;Patarca,R;Rosen,C;Wong-Staal,F;Haseltine,W
参与获得性免疫缺陷综合征的逆转录病毒（HTLV-III/LAV）含有一个区域，该区域对于刺激由病毒长末端重复序列指导的基因表达是必需的。该区域位于核苷酸5365和5607之间，紧邻包膜基因5 '。含有该区域的双剪接信息可以编码一个86个氨基酸的蛋白质，其结构特征与核酸结合蛋白相似。
The retrovirus involved in acquired immune deficiency syndrome (HTLV-III/LAV) contains a region that is necessary for stimulation of gene expression directed by the viral long terminal repeat. This region is located between nucleotides 5365 and 5607, immediately 5′ to the envelope gene. A doubly-spliced message containing this region could encode an 86-amino acid protein with structural features similar to those of nucleic acid-binding proteins.