Therapeutic prospects of metabolically active brown adipose tissue in humans.
Therapeutic prospects of metabolically active brown adipose tissue in humans.
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DOI：
10.3389/fendo.2011.00086
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发表时间：
2011
影响因子：
5.2
通讯作者：
Enerbäck S
中科院分区：
文献类型：
--
作者：
Betz MJ;Enerbäck S
全球肥胖流行对人类健康和福祉构成严重威胁，并对医疗保健系统构成重大挑战。目前的治疗方法主要依靠减少能量摄入和/或增加运动能量消耗，通常效果有限。以前认为只存在于儿童中，但最近证明健康成年人中也存在代谢活跃的棕色脂肪组织（BAT）。 BAT的生理作用是在寒冷环境中将化学能（主要来自脂肪酸）消散为热量以维持体温。最近的研究表明，BAT 的活性与超重和肥胖呈负相关，这一发现提出了基于增加 BAT 能量消耗的新的有效减肥疗法的令人兴奋的可能性，这一过程可能适合药物干预。
The world-wide obesity epidemic constitutes a severe threat to human health and wellbeing and poses a major challenge to health-care systems. Current therapeutic approaches, relying mainly on reduced energy intake and/or increased exercise energy expenditure, are generally of limited effectiveness. Previously believed to be present only in children, the existence of metabolically active brown adipose tissue (BAT) was recently demonstrated also in healthy human adults. The physiological role of BAT is to dissipate chemical energy, mainly from fatty acids, as heat to maintain body temperature in cold environments. Recent studies indicate that the activity of BAT is negatively correlated with overweight and obesity, findings that raise the exciting possibility of new and effective weight reduction therapies based on increased BAT energy expenditure, a process likely to be amenable to pharmacological intervention.