Efficacy and safety of a monodisperse solid-in-oil-in-water emulsion in transcatheter arterial chemoembolization in a rabbit VX2 tumor model
Efficacy and safety of a monodisperse solid-in-oil-in-water emulsion in transcatheter arterial chemoembolization in a rabbit VX2 tumor model
复制标题
单分散水包油包固体乳剂用于兔 VX2 肿瘤模型经导管动脉化疗栓塞的疗效和安全性
DOI：
10.1101/759316
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发表时间：
2019
期刊：
影响因子：
--
通讯作者：
Kumita Shin-ichiro
中科院分区：
文献类型：
--
作者：
Yasui Daisuke;Yamane Aya;Itoh Hiroshi;Kobayashi Masayuki;Kumita Shin-ichiro
经导管动脉化疗栓塞术（TACE）是不可切除的肝细胞癌的标准治疗方法;然而，它并不总是导致肿瘤控制。然而，治疗结果可以改善与单分散乳剂的抗癌剂。在本研究中，在日本白色家兔中评价了单分散Miriplatin-Lipiodol乳剂的有效性和安全性。将VX 2肿瘤植入每只兔的左肝叶中。将动物分为对照组和实验组（每组5只动物），分别通过左肝动脉给予常规米铂混悬液或乳剂。在TACE前、TACE后即刻和TACE后2天进行计算机断层扫描（CT）。术后2天处死所有家兔。切除每个肿瘤并切成两半，通过质谱法评估一半的碘浓度，并评价另一半的碘油蓄积和不良事件。使用TACE前后拍摄的CT平片测量平均亨氏单位（HU）值。实验组的碘浓度[1100（750-1500）ppm]高于对照组[840（660-1800）ppm]。此外，TACE后即刻[199.6（134.0- 301.7）vs. 165.3（131.4-280.5）]和TACE后2天[114.2（56.1-229.8）vs. 58.3（42.9-132.5）]，实验组的HU值高于对照组。在对照组的一只家兔中观察到胆管炎。在任何组中均未观察到缺血性胆管损伤。结果表明，使用单分散乳剂可改善碘油在VX 2肿瘤中的蓄积和滞留。此外，没有与使用乳剂相关的显著不良事件。
Transcatheter arterial chemoembolization (TACE) is a standard treatment for unresectable hepatocellular carcinoma; however, it does not always result in tumor control. Nevertheless, treatment outcome can be improved with monodisperse emulsions of anticancer agents. In this study, the efficacy and safety of a monodisperse miriplatin-Lipiodol emulsion were evaluated in Japanese white rabbits. VX2 tumor was implanted into the left liver lobe of each rabbit. The animals were divided into control and experimental groups (of five animals each) and respectively administered a conventional miriplatin suspension or the emulsion via the left hepatic artery. Computed tomography (CT) was performed before, immediately after, and two days following TACE. All rabbits were sacrificed two days after the procedure. Each tumor was removed and cut in half for assessment of iodine concentration in one half by mass spectroscopy and evaluation of Lipiodol accumulation and adverse events in the other half. Mean Hounsfield unit (HU) values were measured using plain CT images taken before and after TACE. Iodine concentration was higher in the experimental group [1100 (750–1500) ppm] than in the control group [840 (660–1800) ppm]. Additionally, the HU value for the experimental group was higher than that for the control group immediately after [199.6 (134.0– 301.7) vs. 165.3 (131.4–280.5)] and two days after [114.2 (56.1–229.8) vs. 58.3 (42.9–132.5)] TACE. Cholecystitis was observed in one rabbit in the control group. Ischemic bile duct injury was not observed in any group. The results show that Lipiodol accumulation and retention in VX2 tumor may be improved by using a monodisperse emulsion. Moreover, no significant adverse events are associated with the use of the emulsion.
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米瑞铂-碘油混悬液的升温效应，可作为肝细胞癌经动脉化疗栓塞化疗药物的潜在用途：体外研究
影响因子：
4.2
作者：
Shinn;H. Urakawa;T. Mitsufuji;Akinobu Osame;H. Higashihara;T. Ohki;K. Yoshimitsu
通讯作者：
K. Yoshimitsu
影响因子：
3.4
作者：
Okusaka, T;Okada, S;Kubo, Y
通讯作者：
Kubo, Y
影响因子：
4.2
作者：
Seko, Yuya;Ikeda, Kenji;Kumada, Hiromitsu
通讯作者：
Kumada, Hiromitsu
影响因子：
3.3
作者：
Iwazawa J;Ohue S;Hashimoto N;Mitani T
通讯作者：
Mitani T
影响因子：
8.9
作者：
Bannangkoon, Kittipitch;Hongsakul, Keerati;Piratvisuth, Teerha
通讯作者：
Piratvisuth, Teerha