Cortical inhibitory and excitatory correlates of depression severity in children and adolescents.
Cortical inhibitory and excitatory correlates of depression severity in children and adolescents.
复制标题
DOI：
10.1016/j.jad.2015.10.020
复制
发表时间：
2016-01-15
影响因子：
6.6
通讯作者：
Croarkin PE
中科院分区：
文献类型：
--
作者：
Lewis CP;Nakonezny PA;Ameis SH;Vande Voort JL;Husain MM;Emslie GJ;Daskalakis ZJ;Croarkin PE
抑郁症严重程度的神经生理学相关性可能在诊断和治疗计划中具有很大的用途。皮层抑制和兴奋性的经颅磁刺激 (TMS) 测量已显示出作为精神病学生物标志物的前景，但之前没有研究研究儿科情绪障碍疾病严重程度的相关性。本研究旨在探讨儿童和青少年抑郁严重程度与 TMS 皮质抑制和兴奋性测量之间的关系。 24 名抑郁症青少年和 22 名健康对照青少年接受了 TMS 测试（皮质静默期 [CSP]、2 毫秒和 4 毫秒刺激间隔 (ISI) 的短间隔皮质内抑制 [SICI-2,-4]、静息运动阈值 [RMT] 以及 10、15 和 20 毫秒 ISI 的皮质内促进 [ICF-10,-15,-20]）。使用抑郁症状快速清单（QIDS-A17-SR）和儿童抑郁评定量表修订版（CDRS-R）评估症状严重程度。在整个样本中，观察到以下显着负相关：CDRS-R和CSP（右半球，ρ=−0.35，p=0.021）； QIDS-A17-SR 和 CSP（左，ρ=−0.33，p=0.031；右，ρ=−0.42，p=0.004）；以及 CDRS-R 和 SICI-4（右，ρ=−0.30，p=0.042）。在健康对照参与者中，QIDS-A17-SR 和右侧 ICF-10 之间还观察到显着负相关； QIDS-A17-SR 和右 ICF-15；和 QIDS-A17-SR 并留下 ICF-20。在抑郁参与者中，QIDS-A17-SR 与双侧 CSP 之间观察到显着负相关； CDRS-R 和双边 ICF-10； CDRS-R 和双边 ICF-15； QIDS-A17-SR 和左 ICF-10； QIDS-A17-SR 和双边 ICF-15。小样本，潜在的发育/年龄和性别相关影响。这些初步结果为儿科人群抑郁严重程度与 GABA 能和谷氨酸能皮质过程功能障碍之间的关系提供了证据。
Neurophysiologic correlates of depression severity potentially have great utility in diagnosis and treatment planning. Transcranial magnetic stimulation (TMS) measures of cortical inhibition and excitability have shown promise as biomarkers in psychiatry, but no prior work has examined correlates of illness severity in pediatric mood disorders. This study sought to examine the relationship between depression severity and TMS measures of cortical inhibition and excitability in children and adolescents. Twenty-four depressed and 22 healthy control youth underwent TMS testing (cortical silent period [CSP], short-interval intracortical inhibition at 2-ms and 4-ms interstimulus intervals (ISIs) [SICI-2,-4], resting motor threshold [RMT] and intracortical facilitation at 10-, 15-, and 20-ms ISIs [ICF-10,-15,-20]). Symptom severity was assessed with the Quick Inventory of Depressive Symptomatology (QIDS-A17-SR) and the Children’s Depression Rating Scale-Revised (CDRS-R). In the overall sample, the following significant negative correlations were observed: CDRS-R and CSP (right hemisphere, ρ=−0.35, p=0.021); QIDS-A17-SR and CSP (left, ρ=−0.33, p=0.031; right, ρ=−0.42, p=0.004); and CDRS-R and SICI-4 (right, ρ=−0.30, p=0.042). Among healthy control participants, additional significant negative correlations were observed between QIDS-A17-SR and right ICF-10; QIDS-A17-SR and right ICF-15; and QIDS-A17-SR and left ICF-20. Among depressed participants, significant negative correlations were observed between QIDS-A17-SR and bilateral CSP; CDRS-R and bilateral ICF-10; CDRS-R and bilateral ICF-15; QIDS-A17-SR and left ICF-10; and QIDS-A17-SR and bilateral ICF-15. Small sample, potential developmental/age- and sex-related effects. These preliminary results provide evidence for a relationship between depression severity and dysfunction in GABAergic and glutamatergic cortical processes in a pediatric population.