Development and physicochemical characterization of alginate composite film loaded with simvastatin as a potential wound dressing
Development and physicochemical characterization of alginate composite film loaded with simvastatin as a potential wound dressing
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DOI：
10.1016/j.carbpol.2015.10.091
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发表时间：
2016-02-10
影响因子：
11.2
通讯作者：
Ng, Shiow-Fern
中科院分区：
文献类型：
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作者：
Rezvanian, Masoud;Amin, Mohd Cairul Iqbal Mohd;Ng, Shiow-Fern
先前的研究已经证明，局部应用辛伐他汀可以通过增加血管生成和淋巴管生成来促进糖尿病小鼠的伤口愈合。本研究旨在配制和表征海藻酸盐复合膜伤口敷料中的辛伐他汀。用于复合膜的生物聚合物是与果胶或明胶共混的海藻酸钠。薄膜的制备和表征基于它们的物理性能，表面形貌，机械强度和流变性。然后，在体外药物释放的膜进行了研究，最后，细胞活力测定进行评估的细胞毒性的档案。从处方前的研究，海藻酸盐/果胶复合膜显示出具有理想的伤口敷料性能和优越的上级机械性能。体外药物释放曲线表明海藻酸/果胶膜产生控制释放药物的曲线，细胞活力测定表明膜是无毒的。总之，海藻酸盐/果胶复合膜适合与辛伐他汀一起配制作为潜在的伤口敷料。(C)2015爱思唯尔有限公司版权所有。
Previously, studies have demonstrated that topical application of simvastatin can promote wound healing in diabetic mice via augmentation of angiogenesis and lymphangiogenesis. This study aimed to formulate and characterize simvastatin in alginate-based composite film wound dressings. Biopolymers used for composite films were sodium alginate blended with pectin or gelatin. The films were prepared and characterized based on their physical properties, surface morphology, mechanical strength and rheology. Then, in vitro drug releases from the films were investigated and, finally, the cell viability assay was performed to assess the cytotoxicity profile. From the pre-formulation studies, alginate/pectin composite film showed to possess desirable wound dressing properties and superior mechanical properties. The in vitro drug release profile revealed that alginate/pectin film produced a controlled release drug profile, and cell viability assay showed that the film was non-toxic. In summary, alginate/pectin composite film is suitable to be formulated with simvastatin as a potential wound dressing. (C) 2015 Elsevier Ltd. All rights reserved.