Neural substrates of emotionally valenced episodic memory: A PET study using film stimuli
Neural substrates of emotionally valenced episodic memory: A PET study using film stimuli
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DOI：
10.1111/j.1440-1819.2006.01527.x-i1
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发表时间：
2006-03
影响因子：
11.9
通讯作者：
Yoshihiro Masaki;T. Nishikawa;Y. Ikejiri;H. Tokunaga;Naoki Hatta;T. Uema;H. Kazui;Talant K. Doronbekov;Atsushi Ogino;Noriko Miyoshi;H. Tanii;Toshihisa Tanaka;N. Oku;M. Takeda
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作者：
Yoshihiro Masaki;T. Nishikawa;Y. Ikejiri;H. Tokunaga;Naoki Hatta;T. Uema;H. Kazui;Talant K. Doronbekov;Atsushi Ogino;Noriko Miyoshi;H. Tanii;Toshihisa Tanaka;N. Oku;M. Takeda
摘要为了揭示创伤后应激障碍（PTSD）的发病机制，我们在健康被试中模拟PTSD的“再体验”症状，并通过情绪（恐惧）情景记忆任务和几个对比任务的PET激活实验研究其神经基质。10名右撇子健康男性志愿者接受了H215O‐PET检查。每个受试者都被要求在前一天看一部恐怖片。在PET扫描过程中，在可怕的高潮场景之前，受试者被播放了60秒的电影片段，并被要求回忆接下来的场景。实验对象并没有直接观看这一场景，而是重新体验了扳机引发的恐惧。用SPM99分析了该任务与对照任务的rCBF。使用模拟量表评估受试者在每个任务中的主观情绪状态。与情绪性情景记忆任务相比，rCBF与情绪性情景记忆任务显著相关的主要脑区是左脾后皮层（Brodmann's区：ba31）、左视觉关联皮层（ba19）和右前额叶皮层（ba10）。尽管脾后皮层或后扣带回被认为只参与处理情绪记忆或仅处理情景记忆，但该区域被认为参与处理“情绪性情景记忆”。
Abstract To reveal the pathogenetic mechanism of post‐traumatic stress disorder (PTSD), we modeled the ‘re‐experience’ symptom of PTSD in healthy subjects, and investigated its neural substrates using PET activation experiments on an emotionally (fear) valenced episodic memory task and several contrast tasks. Ten right‐handed healthy male volunteers underwent H215O‐PET. Each subject was required to watch a horror film the previous day. During the PET scan, the subject was shown part of the film for 60 s immediately before the terrifying climax scene and told to recall the following scene. The subject did not watch the scene directly, but re‐experienced fear induced by the trigger. The rCBF in this task compared with that in control tasks was analyzed with SPM99. The subjective emotional state of the subject in each task was evaluated using an analog scale. The main cerebral areas where rCBF significantly correlated with the task of emotionally valenced episodic memory, compared with the novel emotional task, were the left retrosplenial cortex (Brodmann's area: BA 31), the left visual association cortex (BA 19) and the right prefrontal cortex (BA 10). Although the retrosplenial cortex or the posterior cingulate gyrus has been regarded as engaged in processing either only emotion or only episodic memory, this area is considered to be involved in processing ‘emotionally valenced episodic memory’.