Hydrogel Microcapsules with Dynamic pH-Responsive Properties from Methacrylic Anhydride
Hydrogel Microcapsules with Dynamic pH-Responsive Properties from Methacrylic Anhydride
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DOI：
10.1021/acs.macromol.8b00843
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发表时间：
2018-07
期刊：
影响因子：
5.5
通讯作者：
J. Werner;S. Nawar;A. Solovev;D. Weitz
中科院分区：
文献类型：
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作者：
J. Werner;S. Nawar;A. Solovev;D. Weitz
动态微胶囊是一种非常受欢迎的封装剂，具有动态可调的释放曲线，作为主动操纵的微反应器，或作为分子分离和纯化的选择性微阱。这种动态微胶囊只能通过一种非破坏性的触发反应机制来实现，这种机制可以可逆地改变壳膜的渗透性，就像水凝胶一样。然而，由于合成化学与水乳液处理的不相容，直接合成水滴周围的触发反应水凝胶膜而不使用牺牲模板仍然是难以实现的。在这里，我们报告了一种利用反应性酸酐化学制备可逆反应水凝胶微胶囊的简便方法。交联和疏水聚（甲基丙烯酸酐）微胶囊是由微流体双乳液滴模板获得的，可以直接封装亲水性，水悬浮货物…
Dynamic microcapsules are a highly sought-after class of encapsulant for advanced delivery applications with dynamically tunable release profiles, as actively manipulatable microreactors, or as selective microtraps for molecular separation and purification. Such dynamic microcapsules can only be realized with a nondestructive trigger-response mechanism that changes the permeability of the shell membrane reversibly, as found in hydrogels. However, the direct synthesis of a trigger-responsive hydrogel membrane around a water drop without the use of sacrificial templates remains elusive due to the incompatibility of the synthesis chemistry with aqueous emulsion processing. Here, we report on a facile approach to fabricate reversibly responsive hydrogel microcapsules utilizing reactive anhydride chemistry. Cross-linked and hydrophobic poly(methacrylic anhydride) microcapsules are obtained from microfluidic double emulsion drop templating that enables direct encapsulation of hydrophilic, water-suspended cargo ...