Parkinson's disease: diagnostic potential of high-resolution phase difference enhanced MR imaging at 3 T
Parkinson's disease: diagnostic potential of high-resolution phase difference enhanced MR imaging at 3 T
复制标题
DOI：
10.1007/s00330-012-2680-2
复制
发表时间：
2013-04-01
影响因子：
5.9
通讯作者：
Yamashita, Yasuyuki
中科院分区：
文献类型：
--
作者：
Kakeda, Shingo;Korogi, Yukunori;Yamashita, Yasuyuki
目的：确定是否可能使用相差增强成像（PADRE）磁共振成像在个体基础上诊断帕金森病（PD）患者。在健康志愿者中，PADRE将脚神经纤维描绘为低信号强度层，黑质描绘为中等信号强度层，并显示出脚神经纤维和黑质（BCS）之间的清晰边界。共纳入24例PD患者和24例对照组。计算黑质和枕部白质的对比度，两名放射科医生独立审查了关于BCS遮挡的PADRE结果。PD组患者的平均对比明显高于对照组（0.56 vs 0.39, P < 0.01）。与对照组相比，PD患者的任何亚组中PADRE的BCS模糊率明显更高（P < 0.01）。观察BCS遮挡对诊断PD的敏感性、特异性和准确性，放射科医师1分别为92%、88%和90%，放射科医师2分别为83%、88%和85%。PADRE能够在个体基础上将患者的PD识别为脚神经纤维和黑质之间的描述缺失。高分辨率相位差增强的3-T MR成像为帕金森病提供了新的见解相位差成像可以描绘出帕金森病中脚神经纤维和黑质之间的界限。相位差增强成像（PADRE）可以识别帕金森病患者的个体。
To determine whether it is possible to diagnose patients with Parkinson's disease (PD) on an individual basis using magnetic resonance imaging with phase difference enhanced imaging (PADRE).PADRE delineated the crural fibres as a layer of low signal intensity and the substantia nigra as a layer of medium signal intensity in a healthy volunteer, and showed a clear boundary between the crural fibres and the substantia nigra (BCS). Twenty-four PD patients and 24 control subjects were enrolled. Contrast ratios between the substantia nigra and occipital white matter were calculated, and two radiologists independently reviewed the PADRE findings regarding BCS obscuration.Mean contrast ratio in PD patients was significantly higher than in control subjects (0.56 vs 0.39, P < 0.01). The BCS on PADRE was obscured significantly more frequently in any subgroups with PD patients compared with control subjects (P < 0.01). The observation of BCS obscuration had a sensitivity, specificity and accuracy for the diagnosis of PD of 92 %, 88 % and 90 % for radiologist 1 and 83 %, 88 % and 85 % for radiologist 2, respectively.PADRE is able to identify PD in patients as a loss of delineation between the crural fibres and the substantia nigra on an individual basis.aEuro cent High-resolution phase difference enhanced 3-T MR imaging offers new insights into Parkinson's diseaseaEuro cent Phase imaging can delineate the boundary between crural fibres and substantia nigraaEuro cent The boundary between crural fibres and substantia nigra is obscured in Parkinson's diseaseaEuro cent Phase difference enhanced imaging (PADRE) can identify individual patients with Parkinson's disease.