Reproducibility of Retinal Nerve Fiber Layer and Macular Thickness Measurement with the RTVue-100 Optical Coherence Tomograph
Reproducibility of Retinal Nerve Fiber Layer and Macular Thickness Measurement with the RTVue-100 Optical Coherence Tomograph
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DOI：
10.1016/j.ophtha.2009.08.039
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发表时间：
2010-04-01
期刊：
影响因子：
13.7
通讯作者：
Hollo, Gabor
中科院分区：
文献类型：
--
作者：
Garas, Anita;Vargha, Peter;Hollo, Gabor
目的：为了评价用RTVue-100傅立叶域光学相干断层扫描（OCT）装置（Optovue，Inc.，Fremont，CA），并确定4个因素的影响：瞳孔扩张、受试者年龄、影像学检查经验和青光眼严重程度。37名医院参与者（14名正常和高眼压受试者，11名中度青光眼患者和12名重度青光眼患者），均接受了影像学检查，方法：对40名无此经验的连续筛查试验参与者的单眼进行5次成像。对于医院的参与者，在同一天，瞳孔放大后重复测量系列。主要结果测量：期内和期间变异系数（CV）、组内相关系数（ICC）、试验内变异性和重测变异性。结果：对于平均和象限RNFLT参数以及GCC参数，期内ICC在93.9%和99.0%之间变化，批内变异系数在1.95%~ 5.69%之间，批内变异系数在3.11 ~ 9.13 μ m之间。大多数厚度值，所有期内CV和期内变异性值，以及信号强度指数在瞳孔放大后没有显著变化。16个视乳头周围RNFLT区段的内移CV在4.90%~ 11.66%之间。大多数期内CV值随疾病严重程度的增加而显著增加，但平均RNFLT和象限RNFLT参数的试验内变异性（用于与标准数据库进行统计学比较）不受青光眼严重程度的影响。患者年龄和影像学检查经验对术中CV无影响。对于平均值和象限RNFLT以及GCC参数，测试内变异性和期内CV分别占重测变异性和访视间CV的79.1%至98.6%和77.1%至95.0%。结论：使用RTVue-100 OCT进行RNFLT和GCC测量的会话内和会话间重现性对于诊断目的是令人满意的，在正常人和不同青光眼严重程度的患者中。瞳孔放大，年龄和经验，在成像examinations.Financial披露（S）：专有或商业披露后，可能会发现在临床上显着的martens. The再现性没有影响。Ophthalmology 2010;117：738-746（C）2010，美国眼科学会。
Purpose: To evaluate the reproducibility of peripapillary retinal nerve fiber layer thickness (RNFLT) and ganglion cell complex (GCC) measurements made with the RTVue-100 Fourier-domain optical coherence tomography (OCT) device (Optovue, Inc., Fremont, CA) and to determine the influence of 4 factors: pupil dilation, subject age, experience in imaging examinations, and glaucoma severity.Design: Prospective study for evaluation of a diagnostic test.Participants: Thirty-seven hospital-based participants (14 normal and ocular hypertensive subjects, 11 patients with moderate and 12 with severe glaucoma), all experienced in imaging examinations, and 40 consecutive screening trial participants lacking such experience.Methods: One eye of all participants was imaged 5 times. For the hospital-based participants, on the same day the measurement series was repeated after pupil dilation. For determination of intersession reproducibility, measurements were performed again 3 months later.Main Outcome Measures: Intrasession and intersession coefficient of variation (CV), intraclass correlation coefficient (ICC), intratest variability, and test-retest variability.Results: For the average and quadrant RNFLT parameters and the GCC parameters, intrasession ICC varied between 93.9% and 99.0%, intrasession CV between 1.95% and 5.69%, and intratest variability varied between 3.11 and 9.13 mu m. Most thickness values, all intrasession CV and intratest variability values, and the signal strength index were not changed significantly after pupil dilation. Intrasession CV of the 16 peripapillary RNFLT sectors varied between 4.90% and 11.66%. Most intrasession CV values increased significantly with increased disease severity, but intratest variability for average RNFLT and the quadrant RNFLT parameters, which are used for statistical comparison with the normative database, were unaffected by the severity of glaucoma. Patient age and experience in imaging examinations had no influence on intrasession CV. Intratest variability and intrasession CV represented 79.1% to 98.6% and 77.1% to 95.0% of test-retest variability and intervisit CV, respectively, for the average and quadrant RNFLT and the GCC parameters.Conclusions: Intrasession and intersession reproducibility of RNFLT and GCC measurements with the RTVue-100 OCT are satisfactory for diagnostic purposes, both in normals and in patients with different glaucoma severity. Pupil dilation, age, and experience in imaging examinations did not influence reproducibility in a clinically significant manner.Financial Disclosure(s): Proprietary or commercial disclosure may be found after the references. Ophthalmology 2010;117:738-746 (C) 2010 by the American Academy of Ophthalmology.