Prognostic significance of host immune gene polymorphisms, in follicular lymphoma survival
Prognostic significance of host immune gene polymorphisms, in follicular lymphoma survival
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DOI：
10.1182/blood-2006-11-058040
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发表时间：
2007-06-15
期刊：
影响因子：
20.3
通讯作者：
Hartge, Patricia
中科院分区：
文献类型：
--
作者：
Cerhan, James R.;Wang, Sophia;Hartge, Patricia
最近的基因表达数据表明，宿主免疫遗传特征可以预测滤泡性淋巴瘤患者的预后。我们评估了候选免疫基因的种系共同变异与生存相关的假设。在考虑年龄、临床和其他人口统计学因素后，使用Cox模型估计个体snp的风险比（HR）和相应的95%置信区间。278例患者诊断时的中位年龄为57岁，59例（21%）患者在随访期间死亡，存活患者的中位随访时间为59个月（范围27-78个月）。IL8 （rs4073; HRTT = 2.14, 1.26 - 3.63）、IL2（rs2069762; HRGT/TT = 11.80, 1.06- 3.05）、IL12B （rs3212227; HRAC/CC = 1.83, 1.06-3.06）和IL1RN （rs454078; HRAA = 1.93, 1.11-3.34）中的snp是最可靠的生存预测因子。来自这些基因的有害基因型数量的汇总评分与生存率密切相关（P =.001）。将4个snp与临床和人口学因素相结合的风险评分与生存的相关性更强（P . 472）
Recent gene-expression data have suggested that host immune genetic signatures may predict outcomes in patients with follicular lymphoma. We evaluated the hypothesis that germ line common variation in candidate immune genes is associated with survival. Cox models were used to estimate hazard ratios (HR) and corresponding 95% confidence intervals for individual SNPs after accounting for age, clinical, and other demographic factors. The median age at diagnosis of the 278 patients was 57 years, and 59 (21%) of the patients died during follow-up, with a median follow-up of 59 months (range, 27-78 months) for surviving patients. SNPs in IL8 (rs4073; HRTT = 2.14, 1.26 - 3.63), IL2(rs2069762; HRGT/TT = 11.80, 1.06 - 3.05), IL12B (rs3212227; HRAC/CC = 1.83, 1.06-3.06), and IL1RN (rs454078; HRAA = 1.93, 1.11-3.34) were the most robust predictors of survival. A summary score of the number of deleterious genotypes from these genes was strongly associated with survival (P =.001). A risk score that combined the 4 SNPs with the clinical and demographic factors was even more strongly associated with survival (P